Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review.
Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review.
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DOI：
10.1186/s12903-016-0171-6
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发表时间：
2016-02-01
期刊：
影响因子：
2.9
通讯作者：
Chu CH
中科院分区：
文献类型：
--
作者：
Gao SS;Zhang S;Mei ML;Lo EC;Chu CH
作为一种低成本和易于操作的治疗方法，使用专业应用的局部氟化物被批准用于预防龋齿和预防早期釉质龋或白色斑点病变。它也被用来阻止牙本质龋齿。本研究的目的是探讨专业氟治疗在预防和控制儿童龋病的临床效果。使用4个数据库（PubMed、科克伦图书馆、ISI Web of Science和Embase）对1948年至2014年的出版物进行了系统检索。使用的关键词是（氟化物）和（矿化或矿化或阻止）和（儿童龋齿或幼儿龋齿）。筛选最初识别的出版物的标题和摘要。排除有关家用氟化物的临床试验、实验室研究、病例报告、综述、非英文文献及不相关的研究。检索了其余文件的全文。对其余论文的参考书目进行手动筛选，以识别相关文章。共发现2177篇论文，17项随机临床试验纳入本综述。10项研究调查了使用四氟化硅、氟化物凝胶、银二胺氟化物或氟化钠对早期釉质龋的再矿化作用。7项研究报告了使用银二胺氟化物或纳米银氟化物对牙本质龋的抑制作用。对4篇使用5%氟化钠保护漆预防早期釉质龋的文献进行Meta分析，总体上预防釉质龋的百分比为63.6%（95%CI：36.0%-91.2%; p < 0.001）。还对5篇使用38%银二胺氟化物阻止牙本质龋的论文进行了荟萃分析，阻止牙本质龋的总体比例为65.9%（95%CI：41.2%-90.7%; p < 0.001）。5%氟化钠保护漆可预防早期釉质龋，38%银二胺氟化物可有效阻止牙本质龋的发生。
As a low-cost and easily operated treatment, the use of professionally applied topical fluoride was approved for preventing dental caries and remineralising early enamel caries or white spot lesions. It is also used to arrest dentine caries. The aim of this study is to investigate the clinical efficacy of professional fluoride therapy in remineralising and arresting caries in children. A systematic search of publications from 1948 to 2014 was conducted using four databases: PubMed, Cochrane Library, ISI Web of Science and Embase. The key words used were (fluoride) AND (remineralisation OR remineralization OR arresting) AND (children caries OR early childhood caries). The title and abstract of initially identified publications were screened. Clinical trials about home-use fluorides, laboratory studies, case reports, reviews, non-English articles and irrelevant studies were excluded. The full texts of the remaining papers were retrieved. Manual screening was conducted on the bibliographies of the remaining papers to identify relevant articles. A total of 2177 papers were found, and 17 randomised clinical trials were included in this review. Ten studies investigated the remineralising effect on early enamel caries using silicon tetrafluoride, fluoride gel, silver diamine fluoride or sodium fluoride. Seven studies reported an arresting effect on dentine caries using silver diamine fluoride or nano-silver fluoride. Meta-analysis was performed on four papers using 5 % sodium fluoride varnish to remineralise early enamel caries, and the overall percentage of remineralised enamel caries was 63.6 % (95 % CI: 36.0 % - 91.2 %; p < 0.001). Meta-analysis was also performed on five papers using 38 % silver diamine fluoride to arrest dentine caries and the overall proportion of arrested dentine caries was 65.9 % (95 % CI: 41.2 % - 90.7 %; p < 0.001). Professionally applied 5 % sodium fluoride varnish can remineralise early enamel caries and 38 % silver diamine fluoride is effective in arresting dentine caries.