Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer.
Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer.
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DOI：
10.1016/j.biomaterials.2021.121057
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发表时间：
2021-08
期刊：
影响因子：
14
通讯作者：
Hao Zhang;Shengduo Xu;Jishen Zhang;Zifeng Wang;Dingxin Liu;Li Guo;Cheng Cheng-Cheng;Yilong Cheng;Dehui Xu;M. Kong;M. Rong;P. Chu
中科院分区：
文献类型：
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作者：
Hao Zhang;Shengduo Xu;Jishen Zhang;Zifeng Wang;Dingxin Liu;Li Guo;Cheng Cheng-Cheng;Yilong Cheng;Dehui Xu;M. Kong;M. Rong;P. Chu
手术后残留的肿瘤细胞是癌症复发和进展的主要原因，但不幸的是，治疗选择有限。在这项工作中，在放电等离子体的帮助下，在热敏生物凝胶[(聚-DL-丙交酯)-(聚乙二醇)-(聚-DL-丙交酯)，PLEL]上制备了可填充的等离子体激活生物凝胶，用于癌症术后局部治疗。体内数据表明，等离子体激活PLEL生物凝胶(PAPB)消除了切除手术后残留的肿瘤组织，还抑制了原位复发，同时没有表现出明显的全身毒性。 Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effectsin vitro.我们的结果表明，新型等离子体激活生物凝胶是局部术后癌症治疗的有效治疗剂。
Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer.In vivodata show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibitsin siturecurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effectsin vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.