Serum time curve characteristics of a fixed dose of beta-carotene in young and old men.
Serum time curve characteristics of a fixed dose of beta-carotene in young and old men.
复制标题
青年和老年男性固定剂量β-胡萝卜素的血清时间曲线特征。
DOI：
10.1080/07315724.1991.10718156
复制
发表时间：
1991
影响因子：
3.5
通讯作者：
Lucchesi,D
中科院分区：
文献类型：
--
作者：
Sugerman,SB;Mobarhan,S;Bowen,PE;Stacewicz-Sapuntzakis,M;Langenberg,P;Henderson,C;Kiani,R;Friedman,H;Lucchesi,D
本研究的目的是评估与年龄相关的差异，血清β-胡萝卜素的时间曲线响应特性时，β-胡萝卜素剂量与1500千卡的过程中，一天。连续两天，7名老年人（73 +/-4岁）和6名年轻人（24 +/-1岁）每人喂食三顿500千卡的等渗液体配方饮食，其中仅含有微量的β-胡萝卜素。在测试的第一天，没有补充β-胡萝卜素（基线日）。在第二天（试验剂量日）的早餐中喂食15 mg剂量的β-胡萝卜素。在两天连续8小时采集空腹血液和每小时血液样本。在测试β-胡萝卜素剂量后24和48小时抽取额外的血液。两个年龄组之间的基线β-胡萝卜素浓度没有统计学差异，但是，由于个体差异较大，血清时间曲线特征根据空腹β-胡萝卜素水平进行了调整。调整后，年轻受试者的给药后血清β-胡萝卜素反应是2 - 3倍（p小于或等于0.04），通过峰浓度、曲线下面积或血清反应曲线的上升斜率进行评价。除了年龄组可能占这些结果的因素的检查表明，老年人的血清反应可能是身体成分和/或血脂模式的功能比年龄本身。然而，在目前的美国人口中，控制这些因素可能是无效的，这两者都与老龄化密切相关。
The present study was designed to evaluate age-related differences in serum beta-carotene time curve response characteristics when a beta-carotene dose was given in conjunction with 1500 kcal over the course of a day. On two consecutive days, seven old (73 +/− 4 years) and six young (24 +/− 1 years) men were each fed three 500-kcal meals of an isotonic liquid formula diet containing only trace amounts of beta-carotene. On the first day of testing, no supplemental beta-carotene was given (baseline day). A 15 mg dose of beta-carotene was fed with the morning meal on the second day (test dose day). Fasting blood and hourly blood samples were obtained for 8 consecutive hours on both days. Additional blood was drawn 24 and 48 hours after the test beta-carotene dose. There were no statistical differences in baseline beta-carotene concentrations between the two age groups tested, but, because of high individual variability, serum time curve characteristics were adjusted for fasting beta-carotene levels. After adjustment, the postdose serum beta-carotene response was two to three times greater (p less than or equal to 0.04) in young subjects, as evaluated by peak concentration, area under the curve, or ascending slope of the serum response curve. Examination of factors besides age group that may have accounted for these results suggests that the serum response of the elderly may be more a function of body composition and/or serum lipid patterns than of age per se. However, in the present US population, it may not be valid to control for these factors, which are both closely related to aging.