Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus)
Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus)
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DOI：
10.1016/j.resp.2004.09.005
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发表时间：
2005-02-15
影响因子：
2.3
通讯作者：
Burggren, W
中科院分区：
文献类型：
--
作者：
Chan, T;Burggren, W
缺氧会抑制脊椎动物的发育，但对器官特异性影响的程度和时间了解甚少。将鸡胚在发育的第1-6、6-12、12-18或1-18天连续暴露于缺氧（15%O-2）中，随后进行主要器官系统的形态测量。在发育中期测量时，早期缺氧暴露会减少眼睛质量和喙长。肝脏、大脑、心脏、肾脏、胃、肠和骨骼长骨在任何发育阶段都不受缺氧影响。绒毛尿囊膜（CAM）质量是不变的缺氧暴露在早期或中期的发展，但CAM质量在第18天显着增加（40和60%，在后期和连续的人口，分别）在响应缺氧暴露。CAM质量的增加可能会增强氧气输送，从而最大限度地减少缺氧对发育和生长的不利影响。因此，在发育的关键窗口期暴露于低渗会对器官发育产生不同的影响，其中一些随后可以通过额外的孵育（蛋黄质量、眼质量、喙长）得到修复。(C)2004 Elsevier B. V.保留所有权利。
Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O-2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic exposure reduced eye mass and beak length when measured in middle development. Liver, brain, heart, kidneys, stomach, intestines and skeletal long bones were not affected by hypoxia at any developmental stage. The chorioallantoic membrane (CAM) mass was unchanged by hypoxic exposure in early or mid-development, but CAM mass on Day 18 increased strikingly (40 and 60% in late and continuous populations, respectively) in response to hypoxic exposure. The increase in CAM mass presumably enhances oxygen delivery, thus minimizing the detrimental effects of hypoxia on development and growth. Hypoxic exposure at key critical windows in development thus results in differential effects on organ development, some of which can subsequently be repaired through additional incubation (yolk mass, eye mass, beak length). (C) 2004 Elsevier B.V. All rights reserved.