Small-caliber vascular prosthesis prototype based on controlled release of heparin from mesochannels and its enhanced biocompatibility.
Small-caliber vascular prosthesis prototype based on controlled release of heparin from mesochannels and its enhanced biocompatibility.
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DOI：
10.1002/smll.201101270
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发表时间：
2012-05
期刊：
影响因子：
13.3
通讯作者：
Yu Zhou;Kun Li;Jia Yuan Yang;C. Guan;Ying Wang;Chang Liu;J. Zhu
中科院分区：
文献类型：
--
作者：
Yu Zhou;Kun Li;Jia Yuan Yang;C. Guan;Ying Wang;Chang Liu;J. Zhu
在一种新的肝素释放系统的基础上，提出了一种新的小口径血管假体原型，即从中膜通道控制肝素的释放。通过在膨胀的聚四氟乙烯接枝材料上外延生长介孔二氧化硅纳米颗粒，成功地在人工生物材料上构建了介孔通道，从而通过空间限制效应固定化肝素，从而避免了生物活性的损失，使其能够长期释放。通过调节细观结构来调节吸附剂-吸附剂之间的相互作用，从而控制肝素的吸附和释放。由于肝素的持续和持续释放，人工血管的性能大大提高，从而为制备具有高生物相容性的功能性血液接触生物材料开辟了一条新的途径。
A novel small-caliber vascular prosthesis prototype is proposed on the basis of a new heparin release system, that is, the controlled delivery of heparin from mesochannels. Fabrication of mesochannels on artificial biomaterials is successfully achieved through epitaxial growth of mesoporous silica nanoparticles on expanded polytetrafluoroethylene grafts, and thus heparin can be immobilized through a space limitation effect, thereby avoiding the loss of bioactivity and enabling long-lasting release. The adsorption and release of heparin are controlled by adjusting the adsorbate-adsorbent interaction through tailoring the mesostructure. Owing to the continuous and sustained release of heparin, the performances of artificial vessels are greatly improved, thus paving a new way to prepare functional blood-contacting biomaterials with high biocompatibility.