Indole and β-carboline alkaloids from Geissospermum sericeum
Indole and β-carboline alkaloids from Geissospermum sericeum
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DOI：
10.1021/np0101705
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发表时间：
2002-01-01
影响因子：
5.1
通讯作者：
Warhurst, DC
中科院分区：
文献类型：
--
作者：
Steele, JCP;Veitch, NC;Warhurst, DC
吲哚生物碱盖索裂唑啉 (1) 和两种新衍生物盖索裂唑啉 N-4-氧化物 (2) 和 1,2-脱氢盖索裂唑啉 (3) 是从 Geissospermum sericeum 的树皮中与 β-咔啉生物碱黄哌啶 (4) 一起获得的。在耐氯喹 (K1) 和氯喹敏感 (T9-96) 恶性疟原虫中评估了这些化合物的体外抗疟原虫活性。它们的细胞毒性是在人类 (KB) 细胞系中测定的。
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N-4-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.