Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings
Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings
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DOI：
10.1016/j.jns.2005.11.006
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发表时间：
2006-04-15
影响因子：
4.4
通讯作者：
Kira, J
中科院分区：
文献类型：
--
作者：
Su, JJ;Osoegawa, M;Kira, J
血管通透性改变先于多发性硬化(MS)脱髓鞘病变的发展，在尸检的MS病变中常可见血管壁增厚和毛细血管增生。尽管血管生长因子是导致这种血管改变的关键因素，但它们在多发性硬化症中的作用尚未得到广泛研究。因此，我们根据临床分期和亚型检查了各种血管生长因子在多发性硬化症中的作用。采用双抗体夹心酶免疫分析法检测了50例MS患者(27例视神经脊髓型MS和23例普通型MS)和33例健康对照组血清中血管内皮生长因子(VEGF)、酸性和碱性成纤维细胞生长因子(FGF)和血小板衍生生长因子(PDGFs)-AA、-AB和-BB的水平。然后分析生长因子变化与脑和脊髓MR1表现的相关性。无论临床亚型如何，复发组血清血管内皮生长因子水平均显著高于对照组(p=0.0495)和缓解组(p=0.0003)。与对照组相比，传统多发性硬化症患者的基础成纤维细胞生长因子显著增加(p=0.0291)，而视神经脊髓型多发性硬化症患者的基础成纤维细胞生长因子水平无明显增加(p=0.05)。复发时血管内皮生长因子与脊髓病变长度呈显著正相关(r=0.506，p=0.0319)。结果提示，血清中血管内皮生长因子水平的升高可能与MS的复发和脊髓纵向广泛病变的形成有关。(C)2005年Elsevier B.V.所有权利均已撤销。
Vascular permeability changes precede the development of demyelinating lesions ill Multiple Sclerosis (MS), and vessel wall thickening and capillary proliferation are frequently seen in autopsied MS lesions. Although vascular growth factors are critical for inducing Such vascular changes, their involvement in MS has not been extensively Studied. Thus, we examined the involvement of various vascular growth factors in MS according to their clinical phase and subtype. We measured Serum levels of vascular endothelial growth factor (VEGF), acidic and basic fibroblast growth factors (FGF) and platelet-derived growth factors (PDGFs)-AA, -AB and -BB in 50 patients with MS (27 opticospinal MS and 23 conventional MS patients) and 33 healthy controls using sandwich enzyme immunoassays. Correlations between growth factor changes and brain and spinal cord MR1 findings were then analyzed. Serum VEGF concentrations were significantly higher in MS patients in relapse than in controls (p=0.0495) and in MS patients in remission (p=0.0003), irrespective Of clinical Subtype. Basic FGF was significantly increased in conventional MS patients, but not opticospinal MS patients compared with controls (p=0.0291), irrespective of clinical phase. VEGF at relapse showed a significant positive correlation with the length of spinal cord lesions oil MRI (r=0.506, p=0.0319). The results Suggest that ail increase in serum VEGF concentration might be involved in MS relapse and the formation of longitudinally extensive spinal cord lesions. (c) 2005 Elsevier B.V. All rights reseved.