Examining Associations Between Cannabis Use Disorder and Measures of Weekly and Within-Day Cannabis Frequency, Quantity, and Potency in College Students.
Examining Associations Between Cannabis Use Disorder and Measures of Weekly and Within-Day Cannabis Frequency, Quantity, and Potency in College Students.
复制标题
检查大学生大麻使用障碍与每周和当天大麻频率、数量和效力测量之间的关联。
DOI：
10.1089/can.2022.0293
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发表时间：
2023
影响因子：
3.8
通讯作者：
Karoly,HollisC
中科院分区：
文献类型：
--
作者：
Piercey,CiannaJ;Mataczynski,Maggie;Stallsmith,VanessaT;Emery,NoahN;Karoly,HollisC
背景：近年来，大学生大麻使用量显著增加，18-25岁的人患大麻使用障碍(CUD)的风险增加。虽然每周使用大麻的频率是衡量大麻消费的常用指标，但人们对探索更微妙的大麻使用指标越来越感兴趣。目前，检验大麻数量、日内频率和效力变量的临床实用性的研究有限。方法：我们使用来自科罗拉多州617名本科生样本的横断面调查数据。利用分两部分建立模型的方法，研究了会议期间的大麻数量和一天内使用大麻的频率是否与出现任何戒毒症状的几率和所认可的戒毒症状总数有关。我们还检验了大麻花的效力是否与出现任何CUD症状的几率以及在报告其最常用产品的大麻素含量的样本子集(N=288)中认可的CUD症状的总数有关。结果：每周使用鲜花的频率(优势比[OR]=1.27，p<；0.001)和每周集中使用频率(OR=1.1，p=0.044)与出现任何CUD症状的几率增加呈正相关，但大麻数量和日内频率变量没有正相关。此外，没有发现花的效力和认可任何CUD症状的几率之间的联系。在至少认可一种症状的个体中，每周使用鲜花的频率(发生率比=1.06p<；0.001)与总症状数呈正相关，但每周集中使用频率、大麻数量变量和日内频率变量不存在相关性。在支持症状的个体中，花朵效力与总症状计数呈正相关(IRR=1.01，p=0.008)。结论：现有的评估时段内大麻数量和日内大麻使用频率的方法在评估每周大麻使用频率以上的大学生戒毒症状方面可能缺乏临床实用价值。大麻花的效力在评估CUD症状严重程度方面可能被证明是有用的，但进一步的研究是有必要的。
Background:College student cannabis use has increased significantly in recent years, and individuals aged 18–25 are at elevated risk for development of cannabis use disorder (CUD). While weekly cannabis use frequency is a commonly used measure of cannabis consumption, there is increasing scientific interest in exploring more nuanced measures of cannabis use. Currently, limited research exists examining the clinical utility of cannabis quantity, within-day frequency, and potency variables.Methods:We used cross-sectional survey data from a sample of 617 undergraduate students in the state of Colorado. A two-part model-building approach was leveraged to examine whether within-session cannabis quantity and within-day cannabis use frequency were associated with odds of experiencing any CUD symptoms and total number of CUD symptoms endorsed. We also examined whether cannabis flower potency was associated with odds of experiencing any CUD symptoms and total number of CUD symptoms endorsed among a subset (N=288) of the sample who reported knowledge of the cannabinoid content of their most frequently used products.Results:Weekly flower use frequency (odds ratio [OR]=1.27,p<0.001) and weekly concentrate use frequency (OR=1.10,p=0.044) were positively associated with increased odds of experiencing any CUD symptoms, but cannabis quantity and within-day frequency variables were not. In addition, no association was found between flower potency and odds of endorsing any CUD symptoms. Among individuals endorsing at least one symptom, weekly flower use frequency (incident rate ratio [IRR]=1.06,p<0.001) was positively associated with total symptom count, but weekly concentrate use frequency, cannabis quantity variables, and within-day frequency variables were not. Among individuals endorsing symptoms, a positive association was found between flower potency and total symptom count (IRR=1.01,p=0.008).Conclusion:Current methods of assessing within-session cannabis quantity and within-day cannabis use frequency may lack clinical utility in examining college student CUD symptoms over and above weekly cannabis use frequency. Cannabis flower potency may prove useful in assessment of CUD symptom severity, but further research is warranted.