Serum markers of bone metabolism show bone loss in hibernating bears.
Serum markers of bone metabolism show bone loss in hibernating bears.
复制标题
骨代谢的血清标志物显示冬眠熊的骨质流失。
DOI：
10.1097/00003086-200303000-00040
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发表时间：
2003
影响因子：
4.2
通讯作者：
Donahue,HenryJ
中科院分区：
文献类型：
--
作者：
Donahue,SethW;Vaughan,MichaelR;Demers,LaurenceM;Donahue,HenryJ
用血清骨代谢指标研究了冬眠黑熊的废用性骨量减少。在冬季圈养和夏季活动期间采集雄性和雌性野生黑熊的血液样品。进行放射免疫测定，以确定血清浓度的皮质醇，羧基末端交联端肽，和羧基末端前肽的I型前胶原，这是骨吸收和形成的标志物，分别。在冬季冬眠期间，骨吸收标记物显著高于活跃的夏季月份，但骨形成标记物没有变化，表明废用期间骨重建和净骨丢失不平衡。血清皮质醇与骨吸收标记物显著相关，但与骨形成标记物无关。与夏季后期相比，青少年和17岁的熊在再活动期早期的骨形成标记物高出4到5倍。这些发现提出了这样一种可能性，即冬眠的黑熊可能通过维持成骨细胞功能来减少废用期间的骨丢失，并且具有比人类或其他动物更有效的补偿机制来恢复固定引起的骨丢失。
Disuse osteopenia was studied in hibernating black bears (Ursus americanus) using serum markers of bone metabolism. Blood samples were collected from male and female, wild black bears during winter denning and active summer periods. Radioimmunoassays were done to determine serum concentrations of cortisol, the carboxy-terminal cross-linked telopeptide, and the carboxy-terminal propeptide of Type I procollagen, which are markers of bone resorption and formation, respectively. The bone resorption marker was significantly higher during winter hibernation than it was in the active summer months, but the bone formation marker was unchanged, suggesting an imbalance in bone remodeling and a net bone loss during disuse. Serum cortisol was significantly correlated with the bone resorption marker, but not with the bone formation marker. The bone formation marker was four-to fivefold higher in an adolescent and a 17-year-old bear early in the remobilization period compared with the later summer months. These findings raise the possibility that hibernating black bears may minimize bone loss during disuse by maintaining osteoblastic function and have a more efficient compensatory mechanism for recovering immobilization-induced bone loss than that of humans or other animals.