The 24-2 Visual Field Guided Progression Analysis Can Miss the Progression of Glaucomatous Damage of the Macula Seen Using OCT.
The 24-2 Visual Field Guided Progression Analysis Can Miss the Progression of Glaucomatous Damage of the Macula Seen Using OCT.
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DOI：
10.1016/j.ogla.2022.03.007
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发表时间：
2022-11
影响因子：
2.9
通讯作者：
De Moraes, Carlos Gustavo
中科院分区：
文献类型：
--
作者：
Hood, Donald C.;La Bruna, Sol;Tsamis, Emmanouil;Leshno, Ari;Melchior, Bruna;Grossman, Jennifer;Liebmann, Jeffrey M.;De Moraes, Carlos Gustavo
24-2的GPA可能会错过OCT报告上看到的早期青光眼的明显进展。为了更好地了解24-2引导进展分析(GPA)在检测早期青光眼(即24-2 MD优于−6DB)进展方面的有效性，将24-2 GPA方法与基于OCT和24-2和10-2视野(VF)信息的参考标准进行比较。横断面研究。99例99只眼，其中可疑或早期青光眼70只眼(平均偏差大于−6分贝24~2只眼)和29只健康对照组(HC)。所有的眼睛在12到59个月的时间内都有至少4个OCT和VF测试日期。24-2VF试验包括两次基线试验和至少两次随访试验。两次基线测试的平均时间为5.6天(中位数为7天)，最后一次随访测试发生在第一次基线访问后至少一年。商业的24-2 GPA软件，在默认设置下，将眼睛描述为“可能进展”(LP)和“可能进展”(PP)；在本分析中，两者都被认为是“进展”。作为参考标准(RS)，3名作者使用严格的标准和定制的OCT进步报告以及商业24-2和10-2 GPA报告的组合对进步进行评分，以获得与GPA相同的测试日期。RS发现70只患者眼中有10只眼(14%)进展，无一只HC眼进展。24-2 GPA确定70名患者中有13只眼进展(PP或LP)。然而，它只正确地对10个RS进行者中的4个(40%)进行了分类。24-2 GPA漏掉的所有6个RS进行者均显示黄斑进展。此外，24-2 GPA将29只HC中的2只眼确定为进展者，并根据RS确定9只无进展的患者眼。在本研究中的早期青光眼(即24-2 MD>；−6DB)中，24-2 GPA错过了OCT所见的进展，并且表现出相对较高的假阳性率。此外，进展的区域通常包括黄斑。结果表明，包括OCT和/或10-2视野应该可以提高进展的检测。在早期青光眼患者中，24-2青光眼进展分析(GPA)错过了光学相干断层扫描(OCT)检测到的进展。此外，在这些眼睛中进展的区域包括黄斑。
The 24-2 GPA can miss clear progression of early glaucoma seen on OCT reports. To better understand the efficacy of the 24-2 guided progression analysis (GPA) for detecting progression in eyes with early glaucoma (i.e., 24-2 MD better than −6dB), by comparing the 24-2 GPA method to a reference standard based upon a combination of OCT and 24-2 and 10-2 visual field (VF) information. Cross-sectional study. 99 eyes from 99 individuals, including 70 suspect or early glaucomatous eyes (24-2 mean deviation better than −6 dB) and 29 healthy controls (HC). All eyes had at least 4 OCT and VF test dates over a period that ranged from 12 to 59 months. The 24-2 VF tests included two baseline tests and at least two follow-up tests. The two baseline tests were within an average of 5.6 days (median of 7 days), and the last follow-up test occurred at least 1 year after the first baseline visit. The commercial 24-2 GPA software, with default settings, characterized eyes as “Likely Progression” (LP) and “Possible Progression” (PP); both were considered “progressing” for this analysis. For a reference standard (RS), 3 authors graded progression using strict criteria and a combination of a custom OCT progression report, and the commercial 24-2 and 10-2 GPA reports for the same test dates as the GPA. The RS identified 10 (14%) of the 70 patient eyes, and none of the HC eyes, as progressing. The 24-2 GPA identified 13 of the 70 patient eyes as progressing (PP or LP). However, it correctly classified only 4 (40%) of the 10 RS progressors. All 6 of the RS progressors missed by the 24-2 GPA showed progression in the macula. In addition, the 24-2 GPA identified 2 of the 29 HC eyes as progressors, as well as 9 patient eyes without progression based upon the RS. In eyes with early glaucoma (i.e., 24-2 MD >−6dB) in this study, the 24-2 GPA missed progression seen with OCT and exhibited a relatively high rate of false positives. Furthermore, the region progressing typically included the macula. The results suggest that including OCT and/or 10-2 visual fields should improve detection of progression. In patients with early glaucoma, the 24-2 glaucoma progression analysis (GPA) missed progression detected with optical coherence tomography (OCT). Further, the region progressing in these eyes included the macula.
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影响因子：
2
作者：
Hood, Donald C.;Zemborain, Zane Z.;De Moraes, Carlos Gustavo
通讯作者：
De Moraes, Carlos Gustavo
影响因子：
4.4
作者：
Hood, Donald C.;Raza, Ali S.;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
3.6
作者：
Garway-Heath, David F.;Zhu, Haogang;Agiomyrgiannakis, Yannis
通讯作者：
Agiomyrgiannakis, Yannis
影响因子：
4.1
作者：
Diaz-Aleman, V. T.;Anton, A.;Azuara-Blanco, A.
通讯作者：
Azuara-Blanco, A.
影响因子：
4.4
作者：
Hood DC;De Moraes CG
通讯作者：
De Moraes CG