Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.
Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts.
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DOI：
10.3389/fphys.2017.00226
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发表时间：
2017
影响因子：
4
通讯作者：
Díaz-Zuccarini V
中科院分区：
文献类型：
--
作者：
Donadoni F;Pichardo-Almarza C;Bartlett M;Dardik A;Homer-Vanniasinkam S;Díaz-Zuccarini V
新生内膜增生是旁路移植失败的主要原因之一。由于一系列不同的因素，疾病进展因患者而异。在本文中，将使用数学模型来了解个体患者的新生内膜增生，结合生物学实验和患者特定数据的信息来分析疾病的某些方面，特别是关于血管壁上剪切应力引起的机械刺激。通过结合细胞生长的生物化学模型和患者特定的计算流体动力学分析的管腔中的血流，血管的重塑研究通过一种新的计算框架。该框架用于分析1例患者的2例静脉移植旁路：股腘动脉和股远端旁路。然后将每个病例的血管壁重塑和血流分析与临床数据进行比较，并作为更好地了解疾病的潜在工具进行讨论。第一种计算方法的模拟结果显示，这些患者的增生位置总体一致，并证明了使用新的综合建模工具来了解疾病进展的潜力。
Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. By combining a biochemical model of cell growth and a patient-specific computational fluid dynamics analysis of blood flow in the lumen, remodeling of the blood vessel is studied by means of a novel computational framework. The framework was used to analyze two vein graft bypasses from one patient: a femoro-popliteal and a femoro-distal bypass. The remodeling of the vessel wall and analysis of the flow for each case was then compared to clinical data and discussed as a potential tool for a better understanding of the disease. Simulation results from this first computational approach showed an overall agreement on the locations of hyperplasia in these patients and demonstrated the potential of using new integrative modeling tools to understand disease progression.