A Novel Method for Detecting Duchenne Muscular Dystrophy in Blood Serum of mdx Mice.

A Novel Method for Detecting Duchenne Muscular Dystrophy in Blood Serum of mdx Mice.
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DOI:
10.3390/genes13081342
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发表时间:
2022-07-27
期刊:
影响因子:
3.5
通讯作者:
Lednev, Igor K.
Lednev, Igor K.
中科院分区:
生物学3区
文献类型:
--
作者:
Ralbovsky, Nicole M.;Dey, Paromita;Galfano, Andrew;Dey, Bijan K.;Lednev, Igor K.

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杜氏肌营养不良症 (DMD) 是最常见的肌营养不良症,通常影响婴儿期的男性。该疾病会导致骨骼肌进行性无力和萎缩,每年诊断出约 20,000 例新病例。目前,诊断DMD的方法是侵入性的、费力的,并且无法做出准确的早期检测。虽然 DMD 无法治愈,但可用于控制症状的治疗方法有限。因此,迫切需要开发一种简单且非侵入性的方法来尽早准确检测 DMD。拉曼光谱与化学计量分析被证明有潜力满足这一诊断需求。
Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, typically affecting males in infancy. The disease causes progressive weakness and atrophy of skeletal muscles, with approximately 20,000 new cases diagnosed yearly. Currently, methods for diagnosing DMD are invasive, laborious, and unable to make accurate early detections. While there is no cure for DMD, there are limited treatments available for managing symptoms. As such, there is a crucial unmet need to develop a simple and non-invasive method for accurately detecting DMD as early as possible. Raman spectroscopy with chemometric analysis is shown to have the potential to fill this diagnostic need.
DOI: 10.4103/0976-500x.72350
发表时间: 2010-07
影响因子: 0.2
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