MODERATE ALCOHOL INTAKE, INCREASED LEVELS OF HIGH-DENSITY-LIPOPROTEIN AND ITS SUBFRACTIONS, AND DECREASED RISK OF MYOCARDIAL-INFARCTION
MODERATE ALCOHOL INTAKE, INCREASED LEVELS OF HIGH-DENSITY-LIPOPROTEIN AND ITS SUBFRACTIONS, AND DECREASED RISK OF MYOCARDIAL-INFARCTION
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DOI：
10.1056/nejm199312163292501
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发表时间：
1993-12-16
影响因子：
158.5
通讯作者：
HENNEKENS, CH
中科院分区：
文献类型：
--
作者：
GAZIANO, JM;BURING, JE;HENNEKENS, CH
背景以前的研究表明，适量饮酒对冠心病有保护作用。血浆脂蛋白水平的改变代表了这种明显保护作用的一种可能机制。因此，我们在340例心肌梗死患者和相同数量的年龄和性别匹配的对照组中研究了饮酒、血浆脂蛋白水平和心肌梗死风险之间的相互关系。病例患者为年龄小于76岁的男性或女性，无冠状动脉疾病史，从波士顿地区六家医院之一出院，诊断为确诊的心肌梗死。通过食物频率量表估计酒精消耗量。我们观察到饮酒与心肌梗死风险之间存在显著的负相关性（P趋势，
Background. Previous studies have suggested that moderate alcohol intake exerts a protective effect against coronary heart disease. Alterations in plasma lipoprotein levels represent one plausible mechanism of this apparent protective effect.Methods. We therefore examined the interrelation among alcohol consumption, plasma lipoprotein levels, and the risk of myocardial infarction in 340 patients who had had myocardial infarctions and an equal number of age- and sex-matched controls. The case patients were men or women less than 76 years of age with no history of coronary disease who were discharged from one of six hospitals in the Boston area with a diagnosis of a confirmed myocardial infarction. Alcohol consumption was estimated by means of a food-frequency questionnaire.Results. We observed a significant inverse association between alcohol consumption and the risk of myocardial infarction (P for trend,