Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model
Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model
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DOI：
10.1677/erc.1.00871
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发表时间：
2005-03-01
影响因子：
3.9
通讯作者：
Li, KZ
中科院分区：
文献类型：
--
作者：
Chen, JH;Ling, R;Li, KZ
本文研究了阿霉素小脂质体（LADR）经不同途径给药对兔VX2乳腺肿瘤的抗肿瘤作用。家兔接受s.c.或静脉注射，或s.c.结合静脉注射，在肿瘤植入后6周注射LADR。静脉注射途径对乳腺肿瘤和远处转移显示出显著的抑制作用。相比之下，腋窝和纵隔淋巴结的转移在s.c.注射LADR通过i.v.和s.c.这些途径对原发性乳腺肿瘤和局部区域淋巴结、肺和肝中的转移瘤都产生了令人满意的治疗活性，如生长速率减慢、增殖细胞核抗原的mRNA表达降低以及肿瘤细胞的广泛坏死和凋亡所示。结论：小型LADR皮下给药，对乳腺癌的淋巴转移提供了可靠的疗效，通过常规静脉途径的化疗可以被推荐为增强转移性乳腺癌患者化疗效果的有希望的方法。
The antitumor effects of small-sized liposomal Adriamycin (LADR) administered by various routes were investigated in rabbits bearing well-developed VX2 tumors in the mammary gland. Rabbits received s.c. or i.v., or s.c. combined with i.v., injections of LADR 6 weeks after tumor implantation. The i.v. route showed a significant inhibitory effect on breast tumors and distant metastases. In comparison, metastases in axillary and mediastinal lymph nodes were more efficiently inhibited after s.c. injection. LADR administered concurrently by both the i.v. and s.c. routes produced satisfactory therapeutic activities on both primary breast tumors and metastases in local-regional lymph nodes, lungs and liver, as shown by slowed growth rates, decreased mRNA expression of proliferating cell nuclear antigen, and extensive necrosis and apoptosis of tumor cells. It is concluded that small-sized LADR administered s.c. provides reliable efficacy on lymphatic metastases of breast cancer and that the addition of treatment by the s.c. route to that by the conventional i.v. route can be recommended as a promising procedure to enhance chemotherapeutic effects in patients with metastatic breast cancer.