EFFECT OF ORAL ETHANOL INTAKE ON MUSCLE SYMPATHETIC-NERVE ACTIVITY AND CARDIOVASCULAR FUNCTIONS IN HUMANS
EFFECT OF ORAL ETHANOL INTAKE ON MUSCLE SYMPATHETIC-NERVE ACTIVITY AND CARDIOVASCULAR FUNCTIONS IN HUMANS
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DOI：
10.1016/0165-1838(95)00022-p
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发表时间：
1995-09-05
期刊：
影响因子：
--
通讯作者：
MANO, T
中科院分区：
文献类型：
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作者：
IWASE, S;MATSUKAWA, T;MANO, T
本研究的目的是阐明饮酒对年轻健康志愿者肌肉交感神经活动和其他心血管变量的急性影响。7名受试者(年龄25.0±4.7岁，体重59.9±5.9 kg)躺在床上，用显微神经学方法记录下胫神经的肌交感神经活动(MSNA)，同时记录心电图、Finapres(R)和血压计的血压、心阻抗图的心输出量和激光多普勒血流仪的皮肤血流量。休息1h后，饮用0.6g/kg酒精，静息105min。血液中的酒精水平表明他们处于中度醉酒状态。心率持续增加，直到摄食后30min，并维持在一个峰值水平。MSNA在摄食后即有轻微但明显的抑制，并逐渐增强，直到实验结束，突发率和总MSNA在摄食后40min和25min与对照组有显著差异。血压先是突然升高，然后逐渐下降，直到摄食后30min，并维持在安静水平，直到实验结束。心输出量在摄食后无恒定趋势，差异不显著，个体间差异较大。摄入后15分钟皮肤血流量增加。我们认为，乙醇对延髓心血管中枢的快速去抑制作用和对外周血管的缓慢扩张作用有助于心率控制和外周交感神经流出到肌肉的不同作用，并构成了血压的三阶段变化。
The aim of the present study was to clarify the acute effect of alcohol drinking on muscle sympathetic nerve activity and other cardiovascular variables in young healthy human volunteers. Seven volunteers (25.0 +/- 4.7 years in age, weighing 59.9 +/- 5.9 kg) were instructed to lay down on a bed, and muscle sympathetic nerve activity (MSNA) was microneurographically recorded from the tibial nerve, simultaneously with an electrocardiogram, blood pressure with Finapres(R) and autosphygmomanometer, cardiac output by impedance cardiography, and skin blood flow by laser Doppler flowmetry. After a 1-h rest, the subjects drank alcohol (0.6 g/kg) and were remained in resting position for 105 min. Blood ethanol levels indicated that they were moderately intoxicated. Heart rate constantly increased until 30 min after the ingestion, and maintained a peak level. MSNA was slightly but significantly suppressed just after the ingestion, and was gradually enhanced until the end of the experiment, showing a significant difference from the control level until 40 min in burst rate and until 25 min in total MSNA after the ingestion. Blood pressure showed an abrupt and transient increase at first, then gradual decrease until 30 min after the ingestion, and maintenance of the resting level until the end of the experiment. Cardiac output showed no constant tendency and no significant differences after the ingestion with wide interindividual variation. Skin blood flow increased 15 min after the ingestion. We conclude that rapidly developing disinhibitory action on medullary cardiovascular center and slowly progressive vasodilative action on peripheral vessels by ethanol contributes to the differential actions on the heart rate control and the peripheral sympathetic outflow to muscles, and configures the three-staged changes in blood pressure.