The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain.
The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain.
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CYP2E1在大脑中的药物代谢或生物活化中的作用。
DOI：
10.1155/2017/4680732
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发表时间：
2017
影响因子：
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通讯作者：
Silva-Adaya D
中科院分区：
文献类型：
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作者：
García-Suástegui WA;Ramos-Chávez LA;Rubio-Osornio M;Calvillo-Velasco M;Atzin-Méndez JA;Guevara J;Silva-Adaya D
生物体有负责清除有毒物质的新陈代谢途径。我们总是认为肝脏是负责人体排毒的主要器官；然而，这个过程发生在许多组织中。与肝脏一样，大脑也表达与外源物质清除相关的代谢途径。除了对亲电剂、活性氧、自由基产物等化合物的解毒作用和外源物质的生物活性外，它还与多种疾病和病理生理条件有关。在这篇综述中，我们描述了在大脑的某些区域中存在I相单加氧酶CYP2E1。我们还探索了诱导蛋白质、mRNA和CYP2E1活性的条件。最后，我们描述了CYP2E1在脑功能障碍中的关系，包括通过代谢与饮酒的行为关系。
Organisms have metabolic pathways that are responsible for removing toxic agents. We always associate the liver as the major organ responsible for detoxification of the body; however this process occurs in many tissues. In the same way, as in the liver, the brain expresses metabolic pathways associated with the elimination of xenobiotics. Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions. In this review, we describe the presence of phase I monooxygenase CYP2E1 in regions of the brain. We also explore the conditions where protein, mRNA, and the activity of CYP2E1 are induced. Finally, we describe the relation of CYP2E1 in brain disorders, including the behavioral relations for alcohol consumption via CYP2E1 metabolism.