Infectious bursal disease virus in poultry: current status and future prospects.
Infectious bursal disease virus in poultry: current status and future prospects.
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DOI：
10.2147/vmrr.s68905
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Rautenschlein S
中科院分区：
文献类型：
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作者：
Alkie TN;Rautenschlein S
传染性法氏囊病病毒（IBDV）感染法氏囊内未成熟的B淋巴细胞，可引起显著的免疫抑制。它仍然是家禽业经济损失的主要原因。IBDV具有分段的双链RNA基因组，易于发生遗传变异。因此，存在具有不同基因型和表型多样性的IBDV分离株。了解病毒的这些特征及其引发的保护性免疫机制对于开发具有改进功效的疫苗是必要的。在这篇综述中，我们强调了病毒进化的模式和预防策略的新发展，主要是新一代疫苗的开发，这将继续成为未来研究和现场应用的兴趣。
Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.