Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa
Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa
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DOI：
10.1167/iovs.16-19686
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发表时间：
2016-08-01
影响因子：
4.4
通讯作者：
Ishibashi, Tatsuro
中科院分区：
文献类型：
--
作者：
Fujiwara, Kohta;Ikeda, Yasuhiro;Ishibashi, Tatsuro
目的。视网膜前膜（ERM）是色素性视网膜炎（RP）患者常见的黄斑并发症。RP中ERM形成的病因在很大程度上是未知的。本研究的目的是探讨眼内炎症的替代指标——眼水耀斑与继发于视网膜炎的ERM之间的关系。我们回顾性研究了117例诊断为典型RP的患者共206只眼睛。在2012年和2013年使用激光耀斑单元计连续测量了水耀斑值。分析了水耀斑测量当天的光谱域光学相干断层扫描图像和眼底照片，用于ERM检测。有ERM的RP患者的房水光斑平均值、年龄、男性频率均显著高于无ERM的RP患者（P < 0.0001, P = 0.007, P = 0.004）。经年龄和性别调整后，水耀斑最高四分位数的眼睛发生ERM的几率显著高于最低四分位数的眼睛（优势比[OR]， 2.68； 95%可信区间[CI]， 1.04-6.93），且在耀斑水平之间的线性趋势显著（P = 0.005）。此外，耀斑值每增加1个对数，发生ERM的可能性就会升高（OR, 2.59; 95% CI, 1.33-5.06）。我们的分析表明，房水耀斑升高与RP继发的ERM有关，这表明炎症可能与RP中ERM形成的发病机制有关。
PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP.METHODS. We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection.RESULTS. The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06).CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.