Clinical features of hospitalised children with 2009 H1N1 influenza virus infection
Clinical features of hospitalised children with 2009 H1N1 influenza virus infection
复制标题
DOI：
10.1007/s00431-010-1255-y
复制
发表时间：
2010-12-01
影响因子：
3.6
通讯作者：
Tovo, Pier-Angelo
中科院分区：
文献类型：
--
作者：
Calitri, Carmelina;Gabiano, Clara;Tovo, Pier-Angelo
2009年H1N1流感病毒在儿科环境中的临床特征和结局尚不明确。对2009年8月至12月期间在意大利一家三级儿科医院确诊感染H1N1流感病毒的儿童的流行病学和临床特征进行了评估。共研究了63名儿童（平均年龄4.3岁），其中29名（46%）患有慢性基础疾病。入院时最常见的症状和体征为发热（97%）、咳嗽（60%）和呼吸紊乱（24%）。40名患者（63.5%）有H1N1相关并发症：32名（51%）肺部疾病，3名（5%）神经系统疾病，如急性脑炎或急性播散性脑脊髓炎，2名（3%）血液学改变。3名患者被送入重症监护室。大多数儿童（81%）接受了奥司他韦治疗：1例在治疗期间出现皮疹;未发现其他不良事件。所有儿童均存活，无后遗症。总之，2009年H1N1流感病毒感染的儿童与广泛的临床表现。神经系统疾病并非例外的并发症。奥司他韦治疗在婴儿中似乎也是安全的。
Clinical features and outcome of 2009 H1N1 influenza virus in the paediatric setting is ill-defined. The epidemiologic and clinical features of children with confirmed H1N1 influenza virus infection admitted to an Italian tertiary paediatric hospital from August through December 2009 were evaluated. A total of 63 children (mean age 4.3 years) were studied; of these, 29 (46%) had chronic underlying diseases. The most frequent symptoms and signs at admission were fever (97%), cough (60%) and respiratory disturbances (24%). Forty patients (63.5%) had H1N1-related complications: 32 (51%) pulmonary diseases, three (5%) neurological disorders, such as acute encephalitis or acute disseminated encephalomyelitis, and two (3%) haematological alterations. Three patients were admitted to the Intensive Care Unit. Most children (81%) were treated with oseltamivir: one developed rash during treatment; no other adverse events were noticed. All children survived without sequelae. In conclusions, 2009 H1N1 influenza virus infection in children is associated with a wide spectrum of clinical manifestations. Neurological disorders are not exceptional complications. Oseltamivir therapy seems safe also in infants.