Variations in affect following amphetamine and placebo: Markers of stimulant drug preference
Variations in affect following amphetamine and placebo: Markers of stimulant drug preference
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DOI：
10.1037/1064-1297.11.1.91
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发表时间：
2003-02-01
影响因子：
2.3
通讯作者：
Gabbay, FH
中科院分区：
文献类型：
--
作者：
Gabbay, FH
在随后的药物偏好过程中，对d-安非他明（选择者，n = 61）或安慰剂（非选择者，n = 48）的健康年轻人进行了d-安非他明和安慰剂影响的变化。在受试者接受安慰剂和10mg d-安非他明治疗前、1小时、3小时和6小时后评估影响。与安慰剂相比，服用安非他明后，选择者在能量、认知效率和幸福感方面的评分有所提高，而在疲劳和镇静方面的评分则有所下降。非选择者报告安非他明没有作用、镇静作用和烦躁作用。服用安慰剂后，选择者的能量、效率和幸福感评分下降，镇静评分上升，而非选择者则没有。服用安慰剂和安非他明后的情绪变化可能构成药物使用风险的标志。
Variations in affect following d-amphetamine and placebo were examined in healthy young adults who subsequently preferred d-amphetamine (choosers; n = 61) or placebo (nonchoosers; n = 48) in a drug preference procedure. Affect was assessed before and 1, 3, and 6 hr after participants received the placebo and 10 mg d-amphetamine. Following amphetamine as compared with placebo, choosers' ratings increased on scales measuring energy, cognitive efficiency, and well-being, and decreased on scales measuring fatigue and sedation. Non-choosers reported no effects, sedative effects, and dysphoric effects of amphetamine. Following placebo, ratings of energy, efficiency, and well-being decreased, and ratings of sedation increased in choosers but not in nonchoosers. Variations in affect following placebo and amphetamine may constitute markers of risk for drug use.