Homotopy with Second-Order Correction Based Backtracking Method for Chemical Process Simulation

Homotopy with Second-Order Correction Based Backtracking Method for Chemical Process Simulation
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基于同伦二阶修正的化工过程模拟回溯法

DOI:
10.1021/ie501139g
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发表时间:
2014-09
期刊:
Industrial & Engineering Chemistry Research
影响因子:
--
通讯作者:
Chen, Xi
Chen, Xi
中科院分区:
其他
文献类型:
--
作者:
Chen, Weifeng;Shao, Zhijiang;Zhu, Lingyu;Chen, Xi

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化工生产过程的设计和管理,包括性能评估和产品质量评价,总是涉及到频繁的模拟。面向方程的方法是过程模拟中最具竞争力的策略之一,但由于化工过程的复杂性和非线性,这种方法很难实现。在这项研究中,同伦为基础的回溯方法(HBM)的模拟改进与二阶校正,它可以计算与低计算成本。为提出的基于同伦二阶修正的回溯方法(SOC-HBM)奠定了理论基础。使用SOC-HBM模拟了分泌蛋白在补料分批反应器、青霉素发酵过程和二元蒸馏塔系统中的生产。
The design and management of chemical manufacturing processes, including performance assessment and product quality evaluation, always involve frequent simulation. The equation-oriented approach is one of the most competitive strategies in process simulation, but this approach is difficult to implement because of the complexity and nonlinearity of chemical processes. In this study, a homotopy-based backtracking method (HBM) for simulation is improved with a second-order correction, which can be calculated with low computational cost. The theoretical foundation for the proposed homotopy with second-order correction based backtracking method (SOC-HBM) is also established. Simulation runs of production of secreted protein in a fed-batch reactor, a penicillin fermentation process, and a binary distillation column system are demonstrated using SOC-HBM.
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