Clinical study of modulated electro-hyperthermia for advanced metastatic breast cancer.
Clinical study of modulated electro-hyperthermia for advanced metastatic breast cancer.
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DOI：
10.3892/mco.2021.2265
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发表时间：
2021-05
影响因子：
1.2
通讯作者：
Fujii T
中科院分区：
文献类型：
--
作者：
Nagata T;Kanamori M;Sekine S;Arai M;Moriyama M;Fujii T
调制电热疗（mEHT）是一种新的治疗模式，以克服与传统的热疗相关的问题; mEHT使用一个精确的阻抗匹配系统和调制射频电流流向恶性肿瘤。它根据恶性细胞的生物物理差异，由于它们的高代谢率，个体（自主）行为和膜状态，选择恶性细胞。本研究的目的是报告mEHT治疗晚期乳腺癌的结局。在10例晚期转移性乳腺癌和复发性疾病患者中检查了mEHT，这些患者被认为是标准治疗方案无法治愈的。在10例患者中，3例达到部分缓解，3例疾病稳定，4例疾病进展;然而，根据他们的主观报告，他们的生活质量得到改善。10例患者均未观察到不良反应。本研究证明了mEHT作为标准治疗失败的晚期乳腺癌病例的可能治疗方法的可行性。此外，mEHT无副作用，可与各种治疗方法联合长期治疗。
Modulated electro-hyperthermia (mEHT) is a new treatment modality developed to overcome the problems associated with traditional hyperthermia; mEHT uses a precise impedance-matched system and modulated radiofrequency current flow to malignant tumors. It selects the malignant cells based on their biophysical differences, due to their high metabolic rate, individual (autonomic) behavior and membrane status. The aim of the present study was to report the outcomes of mEHT in the treatment of advanced breast cancer. mEHT was examined in 10 patients with advanced metastatic breast cancer and recurrent disease, who were considered incurable by standard therapy protocols. Of the 10 patients, partial response was achieved in 3, disease stability in 3, and progressive disease in 4; however, their quality of life was improved based on their subjective reports. No adverse effects were observed in any of the 10 patients. The present study demonstrated the feasibility of mEHT as a possible therapy for advanced breast cancer cases when standard therapies fail. Moreover, mEHT had no side effects and may be combined with various treatments for long-term therapy.
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DOI：
10.1097/00001703-200202000-00008
发表时间：
2002-02-01
影响因子：
2.1
作者：
Cody, HS
通讯作者：
Cody, HS
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影响因子：
16.6
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影响因子：
2.4
作者：
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影响因子：
3.7
作者：
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影响因子：
10.7
作者：
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通讯作者：
Pang, Clifford L. K.