Neuropeptide processing enzymes of the carotid body. Biochemical and immunological characterization of carboxypeptidase activity.
Neuropeptide processing enzymes of the carotid body. Biochemical and immunological characterization of carboxypeptidase activity.
复制标题
颈动脉体的神经肽加工酶。
DOI：
10.1007/978-1-4615-5891-0_48
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发表时间：
1996
影响因子：
--
通讯作者：
Kumar,GK
中科院分区：
文献类型：
--
作者：
Kumar,GK
几项使用免疫细胞化学方法的研究表明，颈动脉小体中存在各种神经肽，它们与神经纤维或I型细胞或血管有关(表1)。此外，出色的电生理学研究表明，外源性神经肽如P物质(McQueen，1980；Prabhakar et al，1989)和内皮素(Chen et al，1994)可增强颈动脉体电活动，而脑啡肽(Monti-Bloch&Eyzaguirre，1985)和心钠素(Wang et al，1991)可减弱颈动脉体电活动。多种神经肽的存在及其对颈动脉小体活动的外源性影响提示，它们可能在颈动脉小体的感觉反应中起重要作用。
Several studies using immunocytochemical approaches have demonstrated that a variety of neuropeptides occur in the carotid body and that they are associated with nerve fibers or type I cells or blood vessels (Table 1). Furthermore, elegant electrophysiological studies showed that carotid body activity is augmented by exogenous administration of neuropeptides like substance P (McQueen, 1980; Prabhakar et al, 1989) and endothelins (Chen et al, 1994) whereas it is attenuated by enkephalins (Monti-Bloch & Eyzaguirre, 1985), and atrial natriuretic peptide (Wang et al, 1991). The occurrence of multiple neuropeptides and their exogenous effects on the activity of the carotid body suggest that they may be of importance in the sensory response of the carotid body.