Blood flow in internal carotid and vertebral arteries during orthostatic stress
Blood flow in internal carotid and vertebral arteries during orthostatic stress
复制标题
DOI：
10.1113/expphysiol.2012.064774
复制
发表时间：
2012-12-01
影响因子：
2.7
通讯作者：
Ogoh, Shigehiko
中科院分区：
文献类型：
--
作者：
Sato, Kohei;Fisher, James P.;Ogoh, Shigehiko
目前尚不清楚立位应激是否会引起脑血流的区域性差异。本研究比较了6名健康青年男性在立位应激(60度仰卧位；HUT)时颈内动脉(ICA)和椎动脉(VA)的血流量。用彩色多普勒超声检测颈内动脉和颈内动脉血流。在仰卧位(仰卧位)和卧位(HUT)状态下，根据双侧股动脉袖带松开引起的急性低血压时ICA和VA的脑血管传导调节率(ROR)，来确定动态的脑自动调节。HUT使颈内动脉血流量减少-9.4+/-1.7%(与仰卧位相比P<；0.01)，ICA电导保持不变。而仰卧位与卧位的VA血流量无显著差异，VA电导增加(+12.9+/-0.8%，P<；0.01)。此外，卧位时颈内动脉和VA的动态脑自动调节均减弱，且颈内动脉的ROR衰减幅度大于颈内动脉[0.23+/-0.02 S-1/0.20+/-0.03 S-1/小屋(-10.6+/-13.4%)]。0.05]。这些数据表明，立位应激引起脑血流的区域性差异，以及两个主要脑血管区域之间可能存在的动态脑血管自我调节的差异，以响应立位应激期间血压的急性变化。
It remains unclear whether orthostatic stress evokes regional differences in cerebral blood flow. The present study compared blood flow in the internal carotid (ICA) and vertebral arteries (VA) during orthostatic stress (60 deg head-up tilt; HUT) in six healthy young men. The ICA and VA blood flow were measured using Doppler ultrasonography. Dynamic cerebral autoregulation was also determined during supine (Supine) and HUT conditions, from the rate of regulation (RoR) in cerebrovascular conductance of the ICA and VA during acute hypotension induced by the release of bilateral thigh-cuffs. The HUT decreased ICA blood flow by -9.4 +/- 1.7% (P < 0.01 versus Supine), leaving ICA conductance unchanged. In contrast, there was no significant difference in VA blood flow between Supine and HUT, and VA conductance increased (+12.9 +/- 0.8%, P < 0.01). In addition, dynamic cerebral autoregulation in both the ICA and VA was attenuated during HUT, and the magnitude of the attenuation in RoR was greater in the VA [0.25 +/- 0.03 s-1 Supine versus 0.16 +/- 0.02 s-1 HUT (-33.9 +/- 5.8%); P < 0.05] compared with the ICA [0.23 +/- 0.02 s-1 Supine versus 0.20 +/- 0.03 s-1 HUT (-10.6 +/- 13.4%); P > 0.05]. These data indicate that orthostatic stress evokes regional differences in cerebral blood flow and possible differences in dynamic cerebral autoregulation between two main brain vascular areas in response to an acute change in blood pressure during orthostatic stress.