Aphapolins A and B: Two Nemoralisin Diterpenoids Isolated from Aphanamixis polystachya (Wall.) R. Parker
Aphapolins A and B: Two Nemoralisin Diterpenoids Isolated from Aphanamixis polystachya (Wall.) R. Parker
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Aphapolins A 和 B：分离的两种 Nemoralisin 二萜类化合物
DOI：
10.1002/ejoc.201700795
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发表时间：
2017-08-17
影响因子：
2.8
通讯作者：
Yuan, Cheng-Shan
中科院分区：
文献类型：
--
作者：
Fang, Fu-Hu;Huang, Wen-Jun;Yuan, Cheng-Shan
Aphapolin A是一种具有独特4/5-稠合环系统的nemoralisin型二萜类化合物，这在以前报道的nemoralisin二萜类化合物中是前所未有的，Aphapolin B是一种新的含有苯并呋喃部分的nemoralisin型二萜类化合物衍生物，沿着一种新的天然产物从Aphanamixis polystachya（Wall.）R.帕克。通过光谱数据、X射线晶体衍射分析和电子圆二色性计算确定了它们的结构和绝对构型。还描述了aphapolins A和B的可能生物合成途径。
Aphapolin A, a nemoralisin-type diterpenoid possessing a unique 4/5-fused-ring system that is unprecedented in previously reported nemoralisin diterpenoid, and aphapolin B, a novel nemoralisin-type diterpenoid derivative containing a benzofuran moiety, along with a new natural product were isolated from Aphanamixis polystachya (Wall.) R. Parker. Their structures and absolute configurations were elucidated by spectroscopy data, X-ray crystallography diffraction analysis, and electronic circular dichroism calculations. Plausible biosynthetic pathways of aphapolins A and B were also delineated.