THE RELATIONSHIP BETWEEN WORM BURDEN AND LEVELS OF A CIRCULATING ANTIGEN (CAA) OF 5 SPECIES OF SCHISTOSOMA IN MICE
THE RELATIONSHIP BETWEEN WORM BURDEN AND LEVELS OF A CIRCULATING ANTIGEN (CAA) OF 5 SPECIES OF SCHISTOSOMA IN MICE
复制标题
DOI：
10.1017/s0031182000064611
复制
发表时间：
1995-07-01
期刊：
影响因子：
2.4
通讯作者：
DEELDER, AM
中科院分区：
文献类型：
--
作者：
AGNEW, A;FULFORD, AJC;DEELDER, AM
本研究检查了测定宿主循环中的寄生虫体特异性抗原（CAA）的量以可靠地反映相对蠕虫负荷的测定方法的能力。用不同剂量的5种噬菌体感染小鼠，血清CAA水平随噬菌体成熟而升高。在所有测试的物种CAA水平与成虫的负担，一旦寄生虫达到性成熟，并保持相对稳定的建立过程中的鸡蛋生产。CAA产生的量在物种之间变化，但在每个物种内CAA水平与蠕虫数量成比例：即使小鼠携带相对于宿主大小非常大的蠕虫负荷，也没有观察到CAA水平的密度依赖性影响。在曼氏血吸虫或曼氏血吸虫中，宿主T细胞剥夺对CAA/虫负荷关系没有影响。在完整的小鼠中，当发生蠕虫繁殖力降低时，血吸虫感染和CAA平衡没有改变。这些数据支持使用CAA作为人类相对较重负担的准确和可靠估计。
This study examines the ability of an assay which measures the amount of a schistosome specific antigen (CAA) in the host circulation to reliably reflect relative worm burden. Mice were infected with 5 species of schistosome with a range of infection dose, The levels of serum CAA increased during schistosome maturation. In all species tested CAA levels correlated well with adult worm burden once the parasites achieved sexual maturity and remained relatively stable during the establishment of egg production. The amount of CAA produced varied between species but within each species CAA levels were proportional to worm numbers: no density-dependent effects on CAA levels were observed even when mice carried worm burdens that were very large relative to host size. T-cell deprivation of the host had no effect on the CAA/worm burden relationship in either Schistosoma mansoni or S. haematobium infections and the CAA equilibrium was unaltered in intact mice when reduction of worm fecundity occurred. These data support the use of the CAA as an accurate and robust estimate of relative schistosome burden in man.