Iron Metabolism in Ferroptosis.
Iron Metabolism in Ferroptosis.
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DOI：
10.3389/fcell.2020.590226
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发表时间：
2020
影响因子：
5.5
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Chen X;Yu C;Kang R;Tang D
铁下垂是一种受调控的细胞死亡形式，其特征是铁依赖的氧化损伤和随后的质膜破裂和与损伤相关的分子模式的释放。由于铁在调节脂质过氧化中的酶活性和产生活性氧的过程中起着重要的作用，铁下垂受到铁代谢的多个方面的调节剂的严格控制，如铁的吸收、储存、利用和外排。铁稳态的翻译和转录调节提供了一个完整的网络来确定铁性下垂的敏感性。铁性下垂与多种铁相关的病理状态或疾病有关，如癌症、神经退行性疾病、缺血再灌注损伤等。了解铁性下垂时铁代谢调控的分子机制可能为铁性下垂相关疾病的治疗提供有效的策略。的确，铁络合剂有效地预防了铁性下垂的发生，这可能为铁相关疾病的治疗提供新的方法。在这篇综述中，我们总结了铁依赖的铁性下垂的理论模型的最新进展，并强调了铁络合剂在疾病中的治疗意义。
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly controlled by regulators involved in many aspects of iron metabolism, such as iron uptake, storage, utilization, and efflux. Translational and transcriptional regulation of iron homeostasis provide an integrated network to determine the sensitivity of ferroptosis. Impaired ferroptosis is implicated in various iron-related pathological conditions or diseases, such as cancer, neurodegenerative diseases, and ischemia-reperfusion injury. Understanding the molecular mechanisms underlying the regulation of iron metabolism during ferroptosis may provide effective strategies for the treatment of ferroptosis-associated diseases. Indeed, iron chelators effectively prevent the occurrence of ferroptosis, which may provide new approaches for the treatment of iron-related disorders. In this review, we summarize recent advances in the theoretical modeling of iron-dependent ferroptosis, and highlight the therapeutic implications of iron chelators in diseases.
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DOI：
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发表时间：
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