Procalcitonin levels in community-acquired pneumonia - correlation with aetiology and severity
Procalcitonin levels in community-acquired pneumonia - correlation with aetiology and severity
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DOI：
10.3109/00365548.2014.945955
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发表时间：
2014-11-01
影响因子：
--
通讯作者：
Hedlund, Jonas
中科院分区：
文献类型：
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作者：
Johansson, Niclas;Kalin, Mats;Hedlund, Jonas
我们研究了社区获得性肺炎 (CAP) 患者入院时的降钙素原 (PCT) 水平及其与病因和严重程度的关系。菌血症患者的中位 PCT 浓度高于无菌血症患者（6.11 μg/L vs 0.34 μg/L，p = 0.0002），非菌血症肺炎球菌病因患者的 PCT 浓度中位数高于感染其他典型细菌的患者（1.18 vs 0.18，p = 0.038），以及肺炎球菌患者与病毒感染患者相比。病因学 （2.43 与 0.24，p = 0.017）。当根据肺炎严重指数 (PSI) 将病原学、菌血症和严重程度纳入逻辑回归分析并以 PCT = 0.5 作为因变量时，非菌血症肺炎球菌病因的比值比 (OR) 为 5.7 (p = 0.008) 和 PSI 4-5 的 3.0 (p = 0.1)。对菌血症和 PSI 4-5 的单独分析显示 OR 分别为 17.5 (p = 0.008) 和 2.7 (p = 0.092)。在 CAP 患者中，高 PCT 似乎是侵袭性疾病和肺炎球菌病因的良好标志。作为严重程度的预测指标，它似乎不太重要。
We studied procalcitonin (PCT) levels at hospital admittance and their association with aetiology and severity in patients with community-acquired pneumonia (CAP). Median PCT concentrations were higher in bacteraemic patients than in those without bacteraemia (6.11 mu g/L vs 0.34 mu g/L, p = 0.0002), in patients with non-bacteraemic pneumococcal aetiology than in those infected with other classic bacteria (1.18 vs 0.18, p = 0.038), and in patients with pneumococcal as compared with viral aetiology (2.43 vs 0.24, p = 0.017). When aetiology, bacteraemia and severity according to the pneumonia severity index (PSI) were included in logistic regression analyses with PCT = 0.5 as a dependent variable, the odds ratio (OR) for non-bacteraemic pneumococcal aetiology was 5.7 (p = 0.008) and 3.0 (p = 0.1) for PSI 4-5. A separate analysis for bacteraemia and PSI 4-5 showed an OR of 17.5 (p = 0.008) and 2.7 (p = 0.092), respectively. In CAP patients, high PCT seems to be a good marker for invasive disease and pneumococcal aetiology. As a predictor of severity it appears to be less important.