Mitochondrial DNA polymorphisms in Thailand
Mitochondrial DNA polymorphisms in Thailand
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DOI：
10.1007/s100380170098
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发表时间：
2001-01-01
影响因子：
3.5
通讯作者：
Horai, S
中科院分区：
文献类型：
--
作者：
Fucharoen, G;Fucharoen, S;Horai, S
来自泰国六个小族群的人线粒体DNA的D环区的核苷酸序列，山地部落（傈僳族和Mussur），泰国，老宋，冲，和原住民酒井，进行了分析。序列进行了比较，从两个省，清迈和孔敬的泰国本土人口。基于对215名泰国人的563-bp序列的比较，观察到137种不同的序列类型。其中，124个是它们各自种群所特有的，而13个是两到五个种群所共有的。基因间COII/tRNA（赖氨酸）9-bp缺失，观察到在每一个泰国人口的检查，除了酒井，不同的频率范围从18%到40%。D-loop序列变异和系统发育分析表明，9-bp缺失发生在东南亚人的一个非常古老的祖先中，尽管不能排除缺失的多个起源。种群间的遗传距离，净核苷酸差异的基础上，揭示了Sakai是远亲的其他泰国人口，而老宋和冲彼此密切相关。密切的遗传亲缘关系，也观察到之间的山部落，泰国，和本土东北泰国（孔敬），这表明他们可能有一定程度的共同祖先母系。
Nucleotide sequences of the D-loop region of human mitochondrial DNA from six small ethnic groups of Thailand i.e., Hill tribes (Lisu and Mussur), Phuthai, Lao Song, Chong, and aboriginal Sakai, were analyzed. The sequences were compared with those of native Thai populations from two provinces, Chiang Mai and Khon Kaen. Based on a comparison of the 563-bp sequences in 215 Thai individuals, 137 different sequence types were observed. Of these, 124 were unique to their respective populations, whereas 13 were shared between two to five populations. The intergenic COII/tRNA(Lys) 9-bp deletion was observed in every Thai population examined, except for the Sakai, with varying frequencies ranging from 18% to 40%. The D-loop sequences variation, and phylogenetic analysis, suggested that the 9-bp deletion had occurred in a very ancient ancestry of Southeast Asians, although multiple origins of the deletion cannot be ruled out. Genetic distances, based on net nucleotide diversities, between populations revealed that the Sakai were distantly related to the other Thai populations, while the Lao Song and Chong were closely related to each other. Close genetic affinities were also observed among the Hill tribes, Phuthai, and native northeast Thai (Khon Kaen), indicating that they may share some degree of the common ancestral maternal lineages.