Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis
Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis
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DOI：
10.1073/pnas.1110024108
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发表时间：
2011-11-22
影响因子：
11.1
通讯作者：
Engel, Andreas K.
中科院分区：
文献类型：
--
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
自发脑活动的相关性提供了了解中枢神经系统大规模组织原则的强大途径。然而，要做出关于认知过程的推论，需要详细了解这些耦合与中枢神经系统结构完整性之间的联系。我们研究了多发性硬化症对自发皮质活动中功能连接模式的影响，多发性硬化症导致中央白质严重解体。使用基于认知病理学显著模式的强度的数据驱动的方法，我们确定了不同的网络，这些网络表现出功能连接的增加，尽管中央白质完整性存在强烈的弥漫性减少。默认模式网络成为这些连接调节的核心目标，在双侧顶下皮质、后扣带回和内侧前额叶皮质显示出增强的功能耦合。这些发现暗示了早期多发性硬化症的解剖和功能连接的复杂和不同的关系，从而为理解认知能力和中枢神经系统的完整性如何反映在功能信号的内在协方差中提供了重要的观察结果。
Correlations in spontaneous brain activity provide powerful access to large-scale organizational principles of the CNS. However, making inferences about cognitive processes requires a detailed understanding of the link between these couplings and the structural integrity of the CNS. We studied the impact of multiple sclerosis, which leads to the severe disintegration of the central white matter, on functional connectivity patterns in spontaneous cortical activity. Using a data driven approach based on the strength of a salient pattern of cognitive pathology, we identified distinct networks that exhibit increases in functional connectivity despite the presence of strong and diffuse reductions of the central white-matter integrity. The default mode network emerged as a core target of these connectivity modulations, showing enhanced functional coupling in bilateral inferior parietal cortex, posterior cingulate, and medial prefrontal cortex. These findings imply a complex and diverging relation of anatomical and functional connectivity in early multiple sclerosis and, thus, add an important observation for understanding how cognitive abilities and CNS integrity may be reflected in the intrinsic covariance of functional signals.