Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.
Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.
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六丙基丙酰环旋植物的合成和早期发育：口服抗氧化病毒核苷磷酸。
DOI：
10.3390/v2102213
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Hostetler KY
中科院分区：
文献类型：
--
作者：
Hostetler KY
Hexadecyloxypropyl-cidofovir (HDP-CDV) is a novel ether lipid conjugate of (S)-1-(3-hydroxy-2-phosphonoylmethoxypropyl)-cytosine (CDV) which exhibits a remarkable increase in antiviral activity against orthopoxviruses compared with CDV. In contrast to CDV, HDP-CDV is orally active and lacks the nephrotoxicity of CDV itself. Increased oral bioavailability and increased cellular uptake is facilitated by the lipid portion of the molecule which is responsible for the improved activity profile. The lipid portion of HDP-CDV is cleaved in the cell, releasing CDV which is converted to CDV diphosphate, the active metabolite. HDP-CDV is a highly effective agent against a variety of orthopoxvirus infections in animal models of disease including vaccinia, cowpox, rabbitpox and ectromelia. Its activity was recently demonstrated in a case of human disseminated vaccinia infection after it was added to a multiple drug regimen. In addition to the activity against orthopoxviruses, HDP-CDV (CMX001) is active against all double stranded DNA viruses including CMV, HSV-1, HSV-2, EBV, adenovirus, BK virus, orf, JC, and papilloma viruses, and is under clinical evaluation as a treatment for human infections with these agents.
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影响因子：
25.7
作者：
BERK, L;SCHALM, SW;DEJONG, M
通讯作者：
DEJONG, M
影响因子：
7.6
作者：
Dal Pozzo, Fabiana;Andrei, Graciela;Snoeck, Robert
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影响因子：
1.3
作者：
Beadle, JR;Kini, GD;Hostetler, KY
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影响因子：
6.4
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影响因子：
3.6
作者：
Aldern, KA;Ciesla, SL;Hostetler, KY
通讯作者：
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