Oculomotor function in the rhesus monkey after deafferentation of the extraocular muscles.
Oculomotor function in the rhesus monkey after deafferentation of the extraocular muscles.
复制标题
眼外肌传入神经阻滞后恒河猴的动眼功能。
DOI：
10.1007/s002210100876
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Tamargo,RJ
中科院分区：
文献类型：
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作者：
Lewis,RF;Zee,DS;Hayman,MR;Tamargo,RJ
眼外肌本体感觉在控制眼球运动中的功能仍不确定。在这项研究中，我们检查了眼外肌双侧本体感觉传入神经阻滞对两只恒河猴眼球运动的影响。在传入神经阻滞之前和之后，我们分析了基线眼排列、眼跳、追踪和前庭眼球运动。我们还检查了视觉介导的眼球对准、眼跳和追踪的适应。无论是剧烈还是在 5 周的研究期间，眼部肌肉的传入神经阻滞均不会影响基线眼部运动控制。此外，视觉介导的眼动亚型适应也不受传入神经阻滞的影响。这些结果表明，灵长类动物的眼部本体感觉不用于眼部运动的即时在线控制，并且在眼部运动功能的适应性修改中不与视觉线索相互作用。我们得出的结论是，传出命令（传出副本）向大脑提供了有关眼睛运动学的足够信息，以实现正常猴子的精确眼球运动控制，并且该信息通过独立于本体感觉的视觉反馈进行修改。我们假设本体感觉可用于在发育过程中校准输出副本，并通过发出来自传出命令的眼球运动信息与本体感觉器官转换的眼睛实际运动之间潜在的不匹配信号来响应扰动。
The function of extraocular muscle proprioception in the control of eye movements remains uncertain. In this study, we examined the effect of bilateral proprioceptive deafferentation of the extraocular muscles on eye movements in two rhesus monkeys. Before and after deafferentation, we analyzed baseline ocular alignment, saccades, pursuit, and vestibular eye movements. We also examined visually mediated adaptation of ocular alignment, saccades, and pursuit. Deafferentation of the eye muscles did not affect baseline ocular motor control, either acutely or over a 5-week period of study. Furthermore, visually mediated adaptation of the eye movement subtypes was also unaffected by deafferentation. These results suggest that ocular proprioception in primates is not used in the immediate, on-line control of eye movements and does not interact with visual cues in the adaptive modification of ocular motor function. We conclude that the efferent command (efference copy) provides sufficient information about eye kinematics to the brain for accurate eye movement control in normal monkeys, and that this information is modified by visual feedback independently of proprioception. We hypothesize that proprioception may be used to calibrate the efference copy during development and in response to perturbations by signaling potential mismatches between eye movement information derived from the efferent command and the actual motion of the eye transduced by the proprioceptive organs.