Multimodal characterization of the human nucleus accumbens
Multimodal characterization of the human nucleus accumbens
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DOI：
10.1016/j.neuroimage.2019.05.019
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发表时间：
2019-09-01
期刊：
影响因子：
5.7
通讯作者：
Halpern, Casey H.
中科院分区：
文献类型：
--
作者：
Cartmell, Samuel C. D.;Tian, Qiyuan;Halpern, Casey H.
延髓核（NAc）的失调与许多神经精神疾病有关。直接靶向该区域的治疗（例如脑深部电刺激）表现出不同的疗效，这可能是由于非特异性靶向功能异质性核。在这里，我们提供了支持这一概念，首先观察不同的行为效应，在人类患者的NAC内的不同位置的直接模拟。这些观察激励分割的NAC到子区域，我们产生的扩散纤维束成像为基础的分析245名年轻的，无关的健康受试者。我们进一步探索这些刺激诱导的行为反应的机制，通过确定最可能的轴突激活使用患者特定的计算模型的子集。我们验证了我们的扩散为基础的分割使用的证据，从几种方式，包括基于MRI的功能和微观结构的措施，人类死后的免疫组织化学染色，和跨物种比较的皮质NAc预测是已知的保守。最后，我们可视化通过一个NAc亚区的个人轴突束在死后的人类样本使用的7T纤维束跟踪证实的3D组织学的通道。总的来说，这些研究结果广泛表征人类NAc亚区，并提供深入了解其结构和功能的差异与立体定向治疗靶向该地区的影响。
Dysregulation of the nucleus accumbens (NAc) is implicated in numerous neuropsychiatric disorders. Treatments targeting this area directly (e.g. deep brain stimulation) demonstrate variable efficacy, perhaps owing to nonspecific targeting of a functionally heterogeneous nucleus. Here we provide support for this notion, first observing disparate behavioral effects in response to direct simulation of different locations within the NAc in a human patient. These observations motivate a segmentation of the NAc into subregions, which we produce from a diffusion-tractography based analysis of 245 young, unrelated healthy subjects. We further explore the mechanism of these stimulation-induced behavioral responses by identifying the most probable subset of axons activated using a patient-specific computational model. We validate our diffusion-based segmentation using evidence from several modalities, including MRI-based measures of function and microstructure, human post-mortem immunohistochemical staining, and cross-species comparison of cortical-NAc projections that are known to be conserved. Finally, we visualize the passage of individual axon bundles through one NAc subregion in a postmortem human sample using CLARITY 3D histology corroborated by 7T tractography. Collectively, these findings extensively characterize human NAc subregions and provide insight into their structural and functional distinctions with implications for stereotactic treatments targeting this region.