Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical.
Low serum calcium: a new, important indicator of COVID-19 patients from mild/moderate to severe/critical.
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低血清钙：COVID-19患者从轻度/中度到重度/危重的新的重要指标
DOI：
10.1042/bsr20202690
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发表时间：
2020-11-30
影响因子：
4
通讯作者：
Yang B
中科院分区：
文献类型：
--
作者：
Zhou X;Chen D;Wang L;Zhao Y;Wei L;Chen Z;Yang B
背景：2019冠状病毒病（COVID - 19）病毒仍在传播，找出病毒感染的初始影响因素对于减少轻症/中症人群数量、预防疾病加重以及器官功能障碍至关重要。
目的：我们对不同血清钙水平的COVID - 19患者展开了研究。
设计：我们依据症状出现后的天数以及COVID - 19的严重程度，检测了患者的血清钙水平。同时，我们还检测了患者血液中的多器官损伤情况以及免疫细胞因子水平。
结果：我们观察到，在病毒感染早期，轻症/中症病例和重症/危重症病例均出现血钙水平偏低的情况，且在早期，重症/危重症病例的血钙水平明显低于轻症/中症病例。我们还发现，血钙水平偏低与重症/危重症多器官损伤相关，在轻症/中症人群中尤为如此。促炎细胞因子白细胞介素 - 6（IL - 6）在轻症/中症和重症/危重症病例中均与血钙变化相关。
结论：我们的研究结果表明，钙平衡是COVID - 19的首要影响因素，也是症状出现初期临床严重程度的生物标志物。钙与病毒相关的多器官损伤以及炎症细胞因子的增加密切相关。我们的研究结果为判断COVID - 19患者从轻症/中症向重症/危重症发展提供了一个新的重要指标：血清钙。
Abstract Background: Coronavirus disease 2019 (COVID-19) virus is still spreading, finding out the initial hits of viral infection is important to minimize the mild/moderate population, prevent disease aggravation and organs dysfunction. Objective: We investigated COVID-19 patients with different serum calcium levels. Design: We checked the serum calcium level of the patients based on days after symptom onset as well as the severity of COVID-19. We also checked multiorgan injuries and immune cytokines level in their blood. Results: Both mild/moderate and severe critical cases we observed showed low calcium level in the early stage of viral infection, while the severe/critical cases showed significant lower calcium level than mild/moderate cases in the early stage. We also found that low calcium level related to severe/critical multiorgan injuries especially in the mild/moderate population. Proinflammatory cytokine IL-6 also correlated to calcium change in both mild/moderate and severe/critical cases. Conclusions: Our finding indicates that calcium balance is a primal hit of COVID-19 and a biomarker of clinical severity at the beginning of symptom onset. Calcium is closely associated with virus-associated multiple organ injuries and the increase in inflammatory cytokines. Our results provide a new, important indicator of COVID-19 patients from mild/moderate to severe/critical: serum calcium.