New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity
New geranyl stilbenes from Dalea purpurea with in vitro opioid receptor affinity
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DOI：
10.1021/np030258d
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发表时间：
2004-01-01
影响因子：
5.1
通讯作者：
Dodson, SL
中科院分区：
文献类型：
--
作者：
Belofsky, G;French, AN;Dodson, SL
从紫茉莉（Dalea purpurea）的有机提取物中分离得到3个新的香叶基二苯乙烯类化合物：pawhuskins A，B，C（1，2，3）。三个化合物的结构经核磁共振和高分辨质谱确证。这些化合物的活性，沿着已知化合物petalostemumol（4）的活性，在体外阿片受体测定中进行了评价。Pawhuskin A（1）显示出四种化合物中最强的活性，Ki值为0.29 +/- 0.11 μ M。
Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a K-i value of 0.29 +/- 0.11 muM.