An object location memory paradigm for older adults with and without mild cognitive impairment
An object location memory paradigm for older adults with and without mild cognitive impairment
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DOI：
10.1016/j.jneumeth.2014.08.020
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发表时间：
2014-11-30
影响因子：
3
通讯作者：
Floeel, Agnes
中科院分区：
文献类型：
--
作者：
Kuelzow, Nadine;Kerti, Lucia;Floeel, Agnes
背景资料：物体位置记忆在日常生活中是至关重要的，并且已知在神经退行性疾病的早期过程中会恶化。新方法：我们将先前建立的学习范式“LOCATO”用于健康的老年人和轻度认知障碍（MCI）患者。现实生活中的建筑物的图片与二维街道地图上的位置相关联，通过在五个训练块的过程中重复“正确”的对象位置配对，然后进行回忆任务。通过按下按钮指示正确/不正确的关联。原来的两个45项集减少到15项集，并在健康的老年人和MCI的学习曲线，回忆，和重新测试effects.Results：两个15项的版本显示出可比的学习曲线和回忆得分在每个组。虽然两组的学习曲线都呈线性增长，但MCI患者的学习和回忆能力明显低于健康对照组。6个月后的重新测试显示只有小的练习效果。与现有方法的比较：LOCATO是一个简单的标准化任务，通过使用现实生活中的刺激，最小化言语编码，避免精细运动反应，结合外显和内隐统计学习，以及允许评估学习曲线和回忆，克服了以前采用的视觉空间任务的几个局限性。结果表明，LOCATO的缩短版本符合要求的一个强大的和生态上有意义的评估对象的位置记忆在老年人与MCI。它现在可以用于系统地评估对象位置记忆的获得及其通过药物或非侵入性脑刺激等辅助疗法的调节。(C)2014爱思唯尔有限公司版权所有。
Background: Object-location memory is critical in every-day life and known to deteriorate early in the course of neurodegenerative disease.New method: We adapted the previously established learning paradigm "LOCATO" for use in healthy older adults and patients with mild cognitive impairment (MCI). Pictures of real-life buildings were associated with positions on a two-dimensional street map by repetitions of "correct" object-location pairings over the course of five training blocks, followed by a recall task. Correct/incorrect associations were indicated by button presses. The original two 45-item sets were reduced to 15 item-sets, and tested in healthy older adults and MCI for learning curve, recall, and re-test effects.Results: The two 15-item versions showed comparable learning curves and recall scores within each group. While learning curves increased linearly in both groups, MCI patients performed significantly worse on learning and recall compared to healthy controls. Re-testing after 6 month showed small practice effects only.Comparison with existing methods: LOCATO is a simple standardized task that overcomes several limitation of previously employed visuospatial task by using real-life stimuli, minimizing verbal encoding, avoiding fine motor responses, combining explicit and implicit statistical learning, and allowing to assess learning curve in addition to recall.Conclusions: Results show that the shortened version of LOCATO meets the requirements for a robust and ecologically meaningful assessment of object-location memory in older adults with and without MCI. It can now be used to systematically assess acquisition of object-location memory and its modulation through adjuvant therapies like pharmacological or non-invasive brain stimulation. (C) 2014 Elsevier B.V. All rights reserved.