A Putative ABC Transporter Confers Durable Resistance to Multiple Fungal Pathogens in Wheat
A Putative ABC Transporter Confers Durable Resistance to Multiple Fungal Pathogens in Wheat
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DOI：
10.1126/science.1166453
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发表时间：
2009-03-06
期刊：
影响因子：
56.9
通讯作者：
Keller, Beat
中科院分区：
文献类型：
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作者：
Krattinger, Simon G.;Lagudah, Evans S.;Keller, Beat
农作物受益于对病原体的抗性，这种抗性在害虫和农作物的多年和多代中都能持续存在。持久的抗病性（可能是部分的或完全的）可由多个基因控制。小麦中一些最具毁灭性的真菌病原体是叶锈病、条锈病和白粉病。小麦基因Lr34对这些病原体的抗性已经持续了50多年。现在世界各地的小麦品种都含有Lr34基因。在此，我们表明LR34蛋白类似于多效耐药亚家族的三磷酸腺苷结合盒转运蛋白。赋予抗性或易感性的Lr34等位基因因三种基因多态性而不同。在成年植株中起作用的Lr34基因会刺激旗叶叶尖和叶缘的类似衰老的过程。
Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.