LHRH antagonists in rhesus and cynomolgus monkeys
LHRH antagonists in rhesus and cynomolgus monkeys
复制标题
恒河猴和食蟹猴中的 LHRH 拮抗剂
DOI：
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复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Borghi
中科院分区：
文献类型：
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作者：
R. Asch;J. Balmaceda;M. Borghi
Kastin and Schally proposed the possibility of the synthesis of inhibitory analogs of LHRH (Kastin et al., 1972). This hypothesis was shown to be correct and polypeptides capable of competing with LHRH for binding in the pituitary and decreasing the secretion of LH and FSH have been synthesized (Pedroza et al., 1977; Coy et al., 1979). Thus, dosages of [d-Phe2,d-Trp3,d-Phe6]LHRH in the range of 1.5 mg per animal completely suppressed spontaneous ovulation in proestrous rats (de la Cruz et al., 1976). These analogs were also found to be effective in inhibiting ovulation in hamsters and rabbits (de la Cruz et al., 1975; Phelps et al., 1977) and decreasing the response to LHRH in some non-human primates including baboons and chimpanzees (Hagino et al., 1977; Gosselin et al., 1979). Clinical studies performed in men with the antagonist [d-Phe2, d-Trp3,d-Phe6 ]LHRH showed that a 90 mgdose could suppress the LH and FSH release in response to 25 μg of LHRH for up to 24 h (Gonzales-Barcena et al., 1977). An antiovulatory effect was shown in women with the same dose of this antagonist (Canales et al., 1980).
LH-RH 拮抗剂 ([N-Ac-D-Trp(1)(3), D-p-Cl-Phe(2), D-Phe(6), D-Ala(10)]-LH- 的作用
影响因子：
2.9
作者：
Balmaceda,JP;Schally,AV;Coy,D;Asch,RH
通讯作者：
Asch,RH
垂体切除的恒河猴的黄体功能。
DOI：
10.1210/jcem-55-1-154
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Asch,RH;Abou-Samra,M;Braunstein,GD;Pauerstein,CJ
通讯作者：
Pauerstein,CJ
在卵巢切除的恒河猴中，黄体生成素释放激素（LRH）的抑制类似物抑制苯甲酸雌二醇对促性腺激素分泌的正反馈：LRH和雌激素之间必要的协同作用的证据。
DOI：
10.1210/jcem-57-2-367
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Asch,RH;Balmaceda,JP;Borghi,MR;Niesvisky,R;Coy,DH;Schally,AV
通讯作者：
Schally,AV