Ophthalmologic features of Parkinson's disease
Ophthalmologic features of Parkinson's disease
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DOI：
10.1212/01.wnl.0000103444.45882.d8
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发表时间：
2004-01-27
期刊：
影响因子：
9.9
通讯作者：
Newman, NJ
中科院分区：
文献类型：
--
作者：
Biousse, V;Skibell, BC;Newman, NJ
帕金森氏病（PD）患者通常主诉视觉功能受损和阅读困难，尽管视力正常。虽然以前的研究已经评估了对比敏感度，色觉，视觉空间处理，幻视，眼球运动，没有系统地评估PD患者的眼部主诉和眼部表现。对30例早期未经治疗的PD患者和31例无神经系统或已知眼部疾病的对照受试者进行了眼科评价，包括视觉主诉、干眼、睑炎、幻视、眨眼率降低、眼睑痉挛和会聚功能不全的频率。PD患者中提示眼表刺激、泪膜改变、幻视、眼睑痉挛、眨眼率降低和会聚幅度降低的眼部主诉比对照受试者更常见。这些发现可能解释了PD患者通常遇到的许多视觉困难。这些眼部异常通常对治疗有反应。
Patients with Parkinson's disease (PD) commonly complain of impaired visual function and difficulty reading, despite normal visual acuity. Although previous studies have evaluated contrast sensitivity, color vision, visuospatial processing, visual hallucinations, and ocular movements, none has systematically evaluated the ocular complaints and ocular findings of PD patients. Thirty patients with early untreated PD and 31 control subjects without neurologic or known ocular diseases were ophthalmologically evaluated for the frequency of visual complaints, dry eyes, blepharitis, visual hallucinations, reduced blink rate, blepharospasm, and convergence insufficiency. Ocular complaints suggesting ocular surface irritation, altered tear film, visual hallucinations, blepharospasm, decreased blink rate, and decreased convergence amplitudes were more common in PD patients than in control subjects. These findings likely account for many of the visual difficulties commonly encountered by PD patients. These ocular abnormalities frequently respond to treatment.