Morphometric Analysis and Linear Measurements of the Scala Tympani and Implications in Cochlear Implant Electrodes.
Morphometric Analysis and Linear Measurements of the Scala Tympani and Implications in Cochlear Implant Electrodes.
复制标题
鼓阶的形态分析和线性测量及其对人工耳蜗植入电极的影响。
DOI：
10.1097/mao.0000000000003848
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ishiyama,Akira
中科院分区：
文献类型：
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作者：
Fujiwara,RanceJT;Ishiyama,Gail;Lopez,IvanA;Ishiyama,Akira
背景：先前对中耳鼓尺寸的研究使用了显微计算机断层扫描或铸造模式，这与组织学标本上可见的显微解剖不能直接相关。方法采用苏木精和伊红组织病理切片对10例无中耳或内耳病史的人颞骨标本进行三维重建。以90度间隔测量鼓室侧壁、中鼓室和磨牙周围位置的高度，以及横截面积。结果鼓膜侧壁垂直高度在0 ~ 180度范围内由1.28 mm下降到0.88 mm，磨牙周高度由1.20 mm下降到0.85 mm。从0°到180°，横截面积从2.29（标准差，0.60）mm 2下降到1.38（标准差，0.13）mm 2 （p= 0.001）。360度后，鼓膜形状由卵形转变为三角形，相应的侧高相对于磨牙周高度明显降低。在耳蜗植入电极尺寸与鼓室测量值之间观察到广泛的可变性。结论本研究首次对鼓膜的高度和横截面积进行了详细的测量，并首次对鼓膜基底转后的形状变化进行了统计表征。这些测量对于了解植入和电极设计过程中耳蜗内损伤的位置具有重要意义。
BackgroundPrevious investigations in scala tympani dimensions have used microcomputed tomography or casting modalities, which cannot be correlated directly with microanatomy visible on histologic specimens.MethodsThree-dimensional reconstructions of 10 archival human temporal bone specimens with no history of middle or inner ear disease were generated using hematoxylin and eosin histopathologic slides. At 90-degree intervals, the heights of the scala tympani at lateral wall, midscala, and perimodiolar locations were measured, along with cross-sectional area.ResultsThe vertical height of the scala tympani at its lateral wall significantly decreased from 1.28 to 0.88 mm from 0 to 180 degrees, and the perimodiolar height decreased from 1.20 to 0.85 mm. The cross-sectional area decreased from 2.29 (standard deviation, 0.60) mm 2 to 1.38 (standard deviation, 0.13) mm 2 from 0 to 180 degrees (p= 0.001). After 360 degrees, the scala tympani shape transitioned from an ovoid to triangular shape, corresponding with a significantly decreased lateral height relative to perimodiolar height. Wide variability was observed among the cochlear implant electrode sizes relative to scala tympani measurements.ConclusionThe present study is the first to conduct detailed measurements of heights and cross-sectional area of the scala tympani and the first to statistically characterize the change in its shape after the basal turn. These measurements have important implications in understanding locations of intracochlear trauma during insertion and electrode design.