Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?
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DOI：
10.1038/nri2522
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发表时间：
2009-04-01
影响因子：
100.3
通讯作者：
Cupedo, Tom
中科院分区：
文献类型：
--
作者：
Vivier, Eric;Spits, Hergen;Cupedo, Tom
粘膜组织位于与外部环境的交界处，不断受到微生物、物理和化学攻击的挑战。为了针对此类挑战提供必要的免疫防御，淋巴结和派尔氏淋巴集结在子宫内形成，以响应来自淋巴组织诱导剂 (LTi) 细胞的诱导信号。正如这篇 Progress 文章中所讨论的，最近的一系列报告已经确定了肠道和扁桃体中产生白细胞介素 22 的粘膜细胞群，这些细胞与 LTi 细胞（通过表达 ROR gamma t）和自然杀伤细胞（通过表达 NKp46）具有相同的特征，并且可能参与粘膜组织的免疫和体内平衡。
Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed in utero in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing ROR gamma t) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.