Effects of passive smoking on heart rate variability, heart rate and blood pressure:: an observational study
Effects of passive smoking on heart rate variability, heart rate and blood pressure:: an observational study
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DOI：
10.1093/ije/dymo31
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发表时间：
2007-08-01
影响因子：
7.7
通讯作者：
Ackermann-Liebrich, Ursula
中科院分区：
文献类型：
--
作者：
Dietrich, Denise Felber;Schwartz, Joel;Ackermann-Liebrich, Ursula
背景 暴露于环境烟草烟雾 (ETS) 已被证明会增加心血管疾病和死亡的风险，而自主神经功能障碍（特别是心率变异性 (HRV) 降低）是心脏病风险增加的预测因素。本研究测试了 ETS 暴露会降低一般人群 HRV 的假设，并讨论了可能的途径。 方法 这项横断面研究于 2001 年至 2003 年间进行，是 SAPALDIA（瑞士成人空气污染和肺部疾病队列研究）研究的一部分。该分析包括 1218 名随机选择的 50 岁及以上的非吸烟者，他们参与了 24 小时心电图记录。其他检查包括访谈、调查健康状况（尤其是呼吸和心血管健康以及与健康相关的行为和接触 ETS）以及血压、身高和体重测量。结果 在家或工作中接触 ETS 超过 2 小时/天的受试者的总功率（95%CI：-26 至 -3%）、低频功率（-28 至 -1%）、低频/高频比（-26 至 -3%）和与在家或工作中未接触 ETS 的受试者相比，HRV 超低频功率为 -18%（-29 至 -4%）。我们还发现，在记录期间暴露于 ETS 的受试者的心率增加了 2.7%（-0.01 至 5.34%）。 结论 在家庭和工作中暴露于 ETS 与老年人群中较低的 HRV 和较高的心率相关。我们的研究结果表明，接触 ETS 会通过扰乱自主神经系统来增加心脏病风险。
Background Exposure to environmental tobacco smoke (ETS) has been shown to increase the risk for cardiovascular diseases and death, and autonomic dysfunction (specifically, reduced heart rate variability (HRV)) is a predictor of increased cardiac risk. This study tests the hypothesis that ETS exposure reduces HRV in the general population and discusses possible pathways.Methods This cross-sectional study was conducted between 2001 and 2003 and is part of the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung Diseases in Adults) study. The analysis included 1218 randomly selected non-smokers aged 50 and above who participated in 24-h electrocardiogram recordings. Other examinations included an interview, investigating health status (especially respiratory and cardiovascular health and health relevant behaviours and exposure to ETS) and measurements of blood pressure, body height and weight.Results Subjects exposed to ETS at home or at work for more than 2 h/day had a difference of - 15% in total power (95%CI: -26 to -3%), low frequency power (-28 to -1%), low/high frequency ratio (-26 to -3%) and -18% (-29 to -4%) in ultralow frequency power of HRV compared with subjects not exposed to ETS at home or work. We also found a 2.7% (-0.01 to 5.34%) higher heart rate during the recording in exposed subjects.Conclusions Exposure to ETS at home and work is associated with lower HRV and with higher heart rate in an ageing population. Our findings suggest that exposure to ETS increases cardiac risk through disturbances in the autonomic nervous system.