ONTOGENY OF CONTROLS OF FOOD INTAKE IN RAT - GI FILL AND GLUCOPRIVATION
ONTOGENY OF CONTROLS OF FOOD INTAKE IN RAT - GI FILL AND GLUCOPRIVATION
复制标题
DOI：
10.1152/ajplegacy.1973.225.1.58
复制
发表时间：
1973-01-01
影响因子：
--
通讯作者：
EPSTEIN, AN
中科院分区：
文献类型：
--
作者：
HOUPT, KA;EPSTEIN, AN
凯瑟琳·豪普和艾伦N。爱泼斯坦。大鼠食物摄入控制的个体发生：GI jll和葡萄糖缺乏。Am. J.Physiol.225（l）：58-66. 1973.在大鼠中研究了食物摄入控制的发展。体重增加是衡量哺乳动物摄入量的指标。从出生起，去甲肾上腺素刺激进食。一天大的大鼠剥夺4小时获得100%以上的非剥夺控制。3-7日龄的乳鸽，剥夺3-5小时也吃得更多，摄入量增加到剥夺后20小时。牛奶和高岭土的胃负荷定量地抑制了随后的摄入。但是水，从胃里迅速排空，没有。2-脱氧-D-葡萄糖（2-DG）产生的葡萄糖缺乏尽管能有效地刺激高血糖，但并没有增加2-21日龄哺乳动物的采食量。2-DG也没有增加喂养21日龄大鼠断奶14天，尽管在该年龄剥夺的有效性。对葡萄糖缺乏的摄食反应直到出生后4-5周龄才开始。从一开始，饥饿刺激摄食，胃肠道充盈抑制摄食，但对摄食的葡萄糖依赖控制直到断奶后才成熟。胃排空;血糖哺乳动物的摄食行为在个体发育过程中经历了戏剧性的转变。它们开始的生活实际上是寄生在母亲身上，从受孕到断奶完全依赖母亲的营养。当摄食行为在出生时突然开始时，它是简单和自动的。它不分喂养和饮用。新生儿只是简单地吸入一种成分固定的液体，既提供食物又提供水。在一个非常短的时间内，通常是几个星期，哺乳期成为一个自由觅食的成年人。单一、简单的摄入模式被转变为一系列复杂的现象，这些现象现已在成年哺乳动物中得到充分研究，特别是在哺乳动物中。
HOUPT, KATHERINE A., AND ALAN N. EPSTEIN. Ontogeny of controls of food intake in the rat: GI jll and glucoprivation. Am. J. Physiol. 225 (l): 58-66. 19 73.-The development of the controls of food intake was studied in the rat. Weight gain was the measure of intake in the suckling. Deprivation stimulated feeding from birth. One-day-old rats deprived for 4 hr gained 100% more than nondeprived controls. Sucklings, 3-7 days old, deprived for 3-5 hr also ate more and intake was increased up to 20 hr following deprivation. Gastric loads of milk and kaolin depressed subsequent intake quantitatively. But water, which empties rapidly from the stomach, did not. Glucoprivation produced by 2-deoxy-D-glucose(2-DG) did not increase intake in sucklings 2-21 days old despite its effectiveness in stimulating hyperglycemia. Nor did 2-DG increase feeding in 21-day-old rats weaned at 14 days despite the effectiveness of deprivation at that age. The feeding response to glucoprivation did not begin until 4-5 weeks of postnatal age. From the outset, deprivation stimulates feeding and gastrointestinal fill suppresses it. But the glucoprivic control of feeding does not mature until well after weaning. gastric emptying; blood glucoseTHE INGESTIVE BEHAVIOR of mammals undergoes a dramatic transformation during ontogeny. They begin life as virtual parasites on their mother, completely dependent on her for nutrition from conception to weaning. When ingestive behavior begins abruptly at birth, it is simple and automatic. It is not differentiated into feeding and drinking. The neonate simply sucks a fluid of fixed composition which provides both food and water. In a remarkably short time, typically a matter of weeks, the suckling becomes a freeforaging adult. The single, simple mode of ingestion is transformed into the set of complex phenomena that are now well studied in the adult mammal, particularly in the