Efficacy of the ketogenic diet in Chinese children with Dravet syndrome: A focus on neuropsychological development
Efficacy of the ketogenic diet in Chinese children with Dravet syndrome: A focus on neuropsychological development
复制标题
生酮饮食对中国 Dravet 综合征儿童的疗效：关注神经心理发展
DOI：
10.1016/j.yebeh.2018.12.016
复制
发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Chen, Chen
中科院分区：
文献类型：
--
作者：
Liu, Fangyun;Peng, Jing;Chen, Chen
目的：在这项回顾性研究中，我们评估了生酮饮食（KD）治疗中国Dravet综合征（DS）儿童的疗效及其对神经心理发育的影响。方法：2014年7月至2017年12月期间，我科共收治了26例患有DS并接受KD治疗的儿童（14例男性）。通过饮食前后的癫痫发作频率来衡量KD的疗效。此外，儿童的神经心理发展，作为评估的Gesell发展时间表，比较之间的KD和非KD组。在3、6、12、18、24和30个月后，923%、84.6%、462%、30.8%、192%和192%的KD保持不变，而38.4%、34.6%、38.4%、23.0%、15.4%、15.4%的患者癫痫发作减少>50%。12名儿童的发育年龄（DA）分项分数，Gesell发育时间表测量，KD开始后增加。然而，儿童的发育商（DQ）的分项分数（年龄调整）后KD下降。在非KD组（40名参与者）中，还观察到DA子评分增加和DQ子评分减少。结果发现，两组之间的DQ分项分数随时间的变化没有差异。结论：KD组12例患儿KD后DA分增高，与非KD组比较，DQ分随时间的变化无显著性差异。对认知和其他神经心理发育结果的影响KD与DS儿童生活需要进一步研究。(C)2018爱思唯尔公司All rights reserved.
Objectives: In this retrospective study, we evaluated the efficacy of the ketogenic diet (KD) treatment in Chinese children with Dravet syndrome (DS) as well as its effect on neuropsychological development.Methods: Twenty-six children (14 male) living with DS and being treated with KD at our department between July 2014 and December 2017 were enrolled in the study. The efficacy of KD was measured by seizure frequency before and after the diet. Additionally, children's neuropsychological development, as evaluated by the Gesell developmental schedule, was compared between the KD and a non-KD group.Results: After 3, 6, 12, 18, 24, and 30 months, 923%, 84.6%, 462%, 30.8%, 192%, and 192% remained on the KD, while 38.4%, 34.6%, 38.4%, 23.0%, 15.4%, and 15.4% showed >50% reduction in seizure. The development age (DA) subscores of 12 children, as measured by the Gesell developmental schedule, increased after commencement of KD. However, children's development quotient (DQ) subscores (age-adjusted) decreased after KD. In the non-KD group (40 participants), an increase of DA subscores and decrease of DQ subscores were also observed. Results found no difference in changes of DQ subscores over time between the two groups. The DQ subscores after the diet in the KD group (20 participants) did not differ significantly when compared to the DQ subscores at same age in the non-KD group (20 patients) (t-test).Conclusions: The DA subscores of 12 children in KD group increased after KD; when compared with that of the non-KD group, no significant difference was observed in respect to the changes of DQ subscore over time. Effects on cognitive and other neuropsychological development outcomes of KD for children living with DS require further study. (C) 2018 Elsevier Inc. All rights reserved.