Comparative vaccination of cattle against Boophilus microplus with recombinant antigen Bm86 alone or in combination with recombinant Bm91
Comparative vaccination of cattle against Boophilus microplus with recombinant antigen Bm86 alone or in combination with recombinant Bm91
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DOI：
10.1046/j.1365-3024.1996.d01-90.x
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发表时间：
1996-05
影响因子：
2.2
通讯作者：
P. Willadsen;D. Smith;G. Cobon;R. McKENNA
中科院分区：
文献类型：
--
作者：
P. Willadsen;D. Smith;G. Cobon;R. McKENNA
牛用来自微小牛蜱的单一重组蜱抗原 Bm86 或两种重组抗原 Bm86 和 Bm91 的组合进行疫苗接种。在三个实验中，评估了牛对蜱虫后续攻击的反应。与单独使用 Bm86 相比，添加 Bm91 抗原在统计学上显着增强了疫苗接种的功效。此外，两种抗原联合疫苗接种不会损害牛对 Bm86 抗原的反应。最后，个体牛对两种抗原的反应是独立的。所有这些结果可能与双抗原疫苗预期功效的增加有关。
Cattle were vaccinated either with a single recombinant tick antigen, Bm86 or with a combination of two recombinant antigens, Bm86 and Bm91 from the tick Boophilus microplus. In three experiments, the responses of cattle to subsequent challenge with the tick were assessed. The addition of the Bm91 antigen enhanced the efficacy of the vaccination over that with Bm86 alone to a statistically significant degree. Moreover, co‐vaccination with two antigens did not impair the response of cattle to the Bm86 antigen. Finally, responses of individual cattle to the two antigens were independent. All of these results may be relevant to the increase in efficacy expected from a dual antigen vaccine.