The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.
The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.
复制标题
寨卡病毒对怀孕的全球威胁：流行病学，临床观点，机制和影响。
DOI：
10.1186/s12916-016-0660-0
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发表时间：
2016-08-03
期刊：
影响因子：
9.3
通讯作者：
Beeson JG
中科院分区：
文献类型：
--
作者：
Boeuf P;Drummer HE;Richards JS;Scoullar MJ;Beeson JG
寨卡病毒（ZIKV）是一种蚊媒黄病毒，新近成为一种重大的全球威胁，特别是对怀孕的威胁。最近在太平洋和中美洲及南美洲发生的重大疫情与新生儿小头畸形和其他中枢神经系统异常的发病率增加有关。妊娠期间ZIKV感染和小头畸形之间的因果关系现在得到了有力的支持。超过20亿人生活在有利于ZIKV传播的地区，预计2016年美洲将有约400万人感染。考虑到目前大流行的规模和怀孕期间感染的严重和长期后果，ZIKV对卫生服务和受影响社区的影响可能是巨大的。这进一步强调了需要对ZIKV进行快速的全球公共卫生和研究响应，以通过开发治疗方法，疫苗和改进的诊断方法来限制和预防其影响。在这里，我们回顾了ZIKV的流行病学;对妊娠的威胁; ZIKV感染的临床后果和更广泛的影响;以及支持新干预措施，诊断和对疾病机制的见解的病毒生物学。
Zika virus (ZIKV) is a mosquito-borne flavivirus that has newly emerged as a significant global threat, especially to pregnancy. Recent major outbreaks in the Pacific and in Central and South America have been associated with an increased incidence of microcephaly and other abnormalities of the central nervous system in neonates. The causal link between ZIKV infection during pregnancy and microcephaly is now strongly supported. Over 2 billion people live in regions conducive to ZIKV transmission, with ~4 million infections in the Americas predicted for 2016. Given the scale of the current pandemic and the serious and long-term consequences of infection during pregnancy, the impact of ZIKV on health services and affected communities could be enormous. This further highlights the need for a rapid global public health and research response to ZIKV to limit and prevent its impact through the development of therapeutics, vaccines, and improved diagnostics. Here we review the epidemiology of ZIKV; the threat to pregnancy; the clinical consequences and broader impact of ZIKV infections; and the virus biology underpinning new interventions, diagnostics, and insights into the mechanisms of disease.