MicroRNA regulation of cancer stem cells.
MicroRNA regulation of cancer stem cells.
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DOI：
10.1158/0008-5472.can-11-1035
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发表时间：
2011-09-15
期刊：
影响因子：
11.2
通讯作者：
Tang DG
中科院分区：
文献类型：
--
作者：
Liu C;Tang DG
癌症干细胞(CSCs)，或具有干细胞特性的癌细胞，已在许多人类肿瘤中被报道，并被认为与肿瘤的发生、治疗耐药、进展、复发和转移有关。尽管CSCs具有潜在的临床重要性，但它是如何在分子水平上被调控的还不是很清楚。MicroRNAs(MiRNAs)是一种小的非编码RNA，在发育过程中对正常的干细胞功能起着关键作用，也是CSCs的重要调节因子。在这篇综述中，我们总结了目前miRNA对各种肿瘤干细胞调控的主要发现，并讨论了我们最近的发现，即miR-34a通过直接抑制CD44来抑制前列腺CSCs和转移。这些最新进展对于理解CSCs如何受到miRNAs网络的复杂调控以及开发专门针对CSCs的基于机制的新型miRNA疗法具有重要意义。
Cancer stem cells (CSCs), or cancer cells with stem cell properties, have been reported in many human tumors and are thought to be responsible for tumor initiation, therapy resistance, progression, relapse, and metastasis. Despite their potential clinical importance, how CSCs are regulated at the molecular level is not well understood. MicroRNAs (miRNAs), small non-coding RNAs that play critical roles in normal stem cell functions during development, have emerged as important regulators of CSCs as well. In this review, we summarize the current major findings of miRNA regulation of various CSCs and discuss our recent findings that miR-34a suppresses prostate CSCs and metastasis by directly repressing CD44. These recent progresses have important implications for understanding how CSCs are intricately regulated by networks of miRNAs and for developing novel mechanism-based miRNA therapeutics that specifically targets CSCs.