Stem cell based gene therapy in prostate cancer.
Stem cell based gene therapy in prostate cancer.
复制标题
前列腺癌中基于干细胞的基因治疗。
DOI：
10.1155/2014/549136
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发表时间：
2014
影响因子：
--
通讯作者：
Song YS
中科院分区：
文献类型：
--
作者：
Kim JH;Lee HJ;Song YS
目前前列腺癌的治疗，尤其是激素难治性前列腺癌，由于细胞毒药物的不良反应，可能会产生深远的医源性后果。自杀基因治疗已被研究为当前化疗的替代方式，因为它能够针对癌细胞进行治疗。然而，经典的自杀基因治疗有几个深刻的副作用，包括由于病毒载体而导致的免疫损害。近年来，干细胞因其归巢作用被认为是一种新的升级的细胞载体或载体。使用基因工程骨髓间充质干细胞或神经干细胞进行自杀基因治疗具有安全的优势，因为前药给药不仅可以消除肿瘤细胞，因此还可以杀死更具耐药性的治疗干细胞。干细胞靶向肿瘤的前药癌症基因治疗的吸引力在于直接在肿瘤内激活前药，从而避免全身毒性。使用干细胞治疗前列腺癌的成就包括胞嘧啶脱氨酶/5-氟胞嘧啶前药系统、单纯疱疹病毒胸苷激酶/更昔洛韦、羧基酯酶/CPT11和干扰素-β。本研究的目的是综述前列腺癌的干细胞治疗，包括其已证实的机制和局限性。
Current prostate cancer treatment, especially hormone refractory cancer, may create profound iatrogenic outcomes because of the adverse effects of cytotoxic agents. Suicide gene therapy has been investigated for the substitute modality for current chemotherapy because it enables the treatment targeting the cancer cells. However the classic suicide gene therapy has several profound side effects, including immune-compromised due to viral vector. Recently, stem cells have been regarded as a new upgraded cellular vehicle or vector because of its homing effects. Suicide gene therapy using genetically engineered mesenchymal stem cells or neural stem cells has the advantage of being safe, because prodrug administration not only eliminates tumor cells but consequently kills the more resistant therapeutic stem cells as well. The attractiveness of prodrug cancer gene therapy by stem cells targeted to tumors lies in activating the prodrug directly within the tumor mass, thus avoiding systemic toxicity. Therapeutic achievements using stem cells in prostate cancer include the cytosine deaminase/5-fluorocytosine prodrug system, herpes simplex virus thymidine kinase/ganciclovir, carboxyl esterase/CPT11, and interferon-beta. The aim of this study is to review the stem cell therapy in prostate cancer including its proven mechanisms and also limitations.
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影响因子：
12.4
作者：
Cavarretta, Ilaria T.;Altanerova, Veronika;Altaner, Cestmir
通讯作者：
Altaner, Cestmir
影响因子：
11.5
作者：
Hung, SC;Deng, WP;Gelovani, JG
通讯作者：
Gelovani, JG
DOI：
10.1016/j.bbamcr.2010.06.009
发表时间：
2010-10-01
影响因子：
5.1
作者：
Abate-Daga, Daniel;Garcia-Rodriguez, Laura;Fillat, Cristina
通讯作者：
Fillat, Cristina
影响因子：
6.4
作者：
Altanerova, Veronika;Cihova, Marina;Altaner, Cestmir
通讯作者：
Altaner, Cestmir
影响因子：
4
作者：
Borlongan, Cesar V.;Kaneko, Yuji;Sanberg, Paul R.
通讯作者：
Sanberg, Paul R.