ENCODING, REMEMBERING AND AWARENESS IN LORAZEPAM INDUCED AMNESIA
ENCODING, REMEMBERING AND AWARENESS IN LORAZEPAM INDUCED AMNESIA
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DOI：
10.1007/bf02246094
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发表时间：
1995-11-01
影响因子：
3.4
通讯作者：
BERNIK, M
中科院分区：
文献类型：
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作者：
CURRAN, HV;BARROW, S;BERNIK, M
在一项对54名健康志愿者的研究中，评估了劳拉西潘(1，2毫克)和安慰剂对编码、记忆和意识的影响。所有被试都在一个水平加工(L-o-p)任务中学习刺激材料。一半的受试者被评估了单词识别的外显记忆任务，另一半的受试者被给予了词干补全的内隐记忆任务。在内隐任务之后，通过提问和受试者在识别他们从词干中完成的实际单词的回忆经验来进一步考察提取意识。在词干补全的内隐任务中发现了L-o-p效应和明显的劳拉西潘损伤，尽管L-o-p和药物效应之间的交互作用只是数据中的一种趋势。然后，劳拉西潘诱导的茎完成损伤可以至少部分解释为被显性提取过程污染，但我们不能排除药物效应在编码时对感知过程的可能作用。对“意识”问题的回答和对后续回忆经验的分析结果表明，被试在内隐任务中没有意识到使用外显提取。结果还重复了先前的发现，即劳拉西潘和L-o-p都独立地影响单词识别的外显记忆任务的成绩。因此，无论最初处理信息的水平如何，药物导致的编码缺陷都会持续存在。
The effects of lorazepam (1,2 mg) and placebo on encoding, remembering and awareness were assessed in a study with 54 healthy volunteers. All subjects studied stimulus materials in a levels of processing (L-o-p) task. Half the subjects were assessed on an explicit memory task of word recognition and the other half were given an implicit memory task of word-stem completion. Following the implicit task, awareness of retrieval was further investigated by questions and by subjects' recollective experience in recognising the actual words they had completed from stems. L-o-p effects and marked lorazepam-induced impairments were found in the implicit task of word-stem completion although the interaction between L-o-p and drug effects emerged only as a trend in the data. Lorazepam-induced impairments on stem-completion may then be explained at least in part as being due to contamination by explicit retrieval processes, but we cannot rule out the possible role of drug effects on perceptual processes at encoding. results from responses to ''awareness'' questions and from analysis of subsequent recollective experience indicated that subjects were not aware of using explicit retrieval during the implicit task. Results also replicated previous findings showing that both lorazepam and L-o-p independently affect performance in an explicit memory task of word recognition. Thus drug-induced deficits at encoding persist regardless of the level at which information is initially processed.