Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907.
Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907.
复制标题
DOI：
10.1016/j.biopsych.2011.06.023
复制
发表时间：
2011-11-01
影响因子：
10.6
通讯作者：
Abi-Dargham, Anissa
中科院分区：
文献类型：
--
作者：
Simpson, Helen Blair;Slifstein, Mark;Bender, James, Jr.;Xu, Xiaoyan;Hackett, Elizabeth;Maher, Michael J.;Abi-Dargham, Anissa
关键词：
Serotonergic abnormalities are hypothesized to contribute to obsessive-compulsive disorder (OCD). This study used positron emission tomography (PET) with the radioligand [11C]MDL 100907 to examine whether the distribution of one of the serotonin receptors, the 5-HT2A receptor, is altered in OCD. Nineteen OCD subjects, free of psychiatric medications and depression, and 19 matched healthy controls underwent PET scans following injection of [11C]MDL 100907. Total distribution volumes (VT) were derived by kinetic analysis using the arterial input function. Two measures of 5-HT2A availability were computed (BPND and BPP). Groups were compared using a region of interest (ROI) analysis and voxelwise analysis of spatially normalized parametric maps. ROIs included cortical regions (orbitofrontal, dorsolateral prefrontal, medial prefrontal, anterior cingulate, temporal, parietal, occipital, and insular cortex) and limbic regions (entorhinal cortex, parahippocampal gyrus, and medial temporal lobe). No significant group differences were observed in [11C]MDL 100907 BPND or BPP in the ROIs or in the voxelwise analysis of BPND maps. There was a significant correlation in the orbitofrontal cortex between [11C] MDL 100907 binding and age of onset, with earlier age of onset associated with higher binding. In contrast to prior reports, people with OCD (free of psychiatric medications and depression) are not characterized as a group by major changes in 5-HT2A availability in cortical or limbic brain regions. Further research is warranted to examine potential differences in 5-HT2A availability between early and late onset OCD and to assess 5-HT2A function in relation to other neurotransmitter systems implicated in OCD.
登录
查看更多内容
影响因子：
6.3
作者：
Hinz, Rainer;Bhagwagar, Zubin;Grasby, Paul M.
通讯作者：
Grasby, Paul M.
影响因子：
6.7
作者：
Okasha, A;Rafaat, M;El Kholi, S
通讯作者：
El Kholi, S
影响因子：
17.7
作者：
Meyer, JH;McMain, S;Links, P
通讯作者：
Links, P
影响因子：
17.7
作者：
Bhagwagar, Zubin;Hinz, Rainer;Grasby, Paul
通讯作者：
Grasby, Paul
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y